| 摘要 | 第1-7页 |
| ABSTRACT | 第7-14页 |
| CHAPTER ONE:INTRODUCTION AND THE THESIS GOALS | 第14-40页 |
| ·:A BRIEF HISTORIC INTRODUCTION TO GOLD NANOPARTICLE | 第14-15页 |
| ·:PURIfICATION AND SIZE SEPARATION OF GOLD NANOPARTICLES | 第15-16页 |
| ·:OXIDATION OF GOLD NANOPARTICLE AND SHORTENING OF NANORODS | 第16-17页 |
| ·:FUNCTIONALIZATION OF GOLD NANOPARTICLES | 第17-21页 |
| ·:Synthesis of nanoparticles in the presence of thiolated ligands | 第17-18页 |
| ·:Ligand exchange method | 第18-19页 |
| ·:Covalent modification | 第19-20页 |
| ·:Electrostatic binding | 第20-21页 |
| ·:GOLD NANOPARTICLE APPLICATIONS | 第21-28页 |
| ·:Localized surface plasmon absorbance | 第21-22页 |
| ·:Enhancement of conventional surface plasmon resonance signal | 第22页 |
| ·:Fluorescence | 第22-24页 |
| ·:Biological imaging | 第24-25页 |
| ·:Surface enhanced Raman scattering (SERS) | 第25-26页 |
| ·:Catalysis | 第26-27页 |
| ·:Cellular drug delivery (therapeutic delivery) | 第27-28页 |
| ·:THESIS GOALS | 第28-30页 |
| REFERENCES | 第30-40页 |
| CHAPTER TWO:PREPARATION OF GOLD NANOPARTICLES | 第40-61页 |
| ·:BACKGROUND | 第40-42页 |
| ·:EXPERIMENTAL | 第42-48页 |
| ·:General procedure | 第42页 |
| ·:Synthesis of thiol-terminated polyethylene glycol | 第42-43页 |
| ·:Preparation of gold nanoparticle in aqueous medium | 第43-46页 |
| ·:Citrate gold Nanoparticle | 第44页 |
| ·:CTAB spherical gold nanoparticle | 第44页 |
| ·:Gold nanorod | 第44-46页 |
| ·:Gold nanoctahedron | 第46页 |
| ·:Gold nanohexagon | 第46页 |
| ·:Preparation of gold nanoparticle in nonaqueous medium | 第46-48页 |
| ·:Burst's method of preparation of alkanethiol gold nanoparticle | 第47页 |
| ·:Preparation of PEGylated gold nanoparticle | 第47-48页 |
| ·:RESULTS AND DISCUSSION | 第48-54页 |
| ·:Gold nanoparticle in aqueous media | 第48-52页 |
| ·:Gold nanoparticle in nonaqueous media | 第52-54页 |
| ·:SUMMARY | 第54-56页 |
| REFERENCES | 第56-61页 |
| CHAPTER THREE:PLASMON COUPLING INTERACTION OF GOLD NANOPARTICLE ANDSURFACE PLASMON WAVE | 第61-82页 |
| ·:BACKGROUND | 第61-63页 |
| ·:EXPERIMENTAL | 第63-65页 |
| ·:Reagents | 第63-64页 |
| ·:Preparation of gold nanoparticles | 第64页 |
| ·:Gold nanoparticles oxidation | 第64页 |
| ·:UV-VIS absorption characterization as the LSPR of gold nanoparticles | 第64页 |
| ·:Transmission electron microscopy | 第64页 |
| ·:Conventional SPR responses of gold nanoparticles and methylene blue | 第64-65页 |
| ·:RESULTS AND DISCUSSION | 第65-76页 |
| ·:Preparation and characterization of gold nanoparticles | 第65-69页 |
| ·:Conventional SPR responses of gold nanorod and methylene blue solutions | 第69-72页 |
| ·:Estimation of the refractive index change as a function of gold nanorod aspect ratio | 第72-74页 |
| ·:SPR response to other gold nanoparticles solutions | 第74-76页 |
| ·:SUMMARY | 第76-78页 |
| REFERENCES | 第78-82页 |
| CHAPTER FOUR:GOLD NANOPARTICLE WITH ANTI-NONSPECIFIC ADSORPTION | 第82-103页 |
| ·:BACKGROUND | 第82-83页 |
| ·:EXPERIMENTAL | 第83-88页 |
| ·:Reagents | 第83页 |
| ·:Instrumentations | 第83页 |
| ·:Synthesis of propargyl-terminated polyethylene glycol thiol 2 | 第83-85页 |
| ·:Synthesis of ferrocene azide 3 | 第85页 |
| ·:Synthesis of amidoferrocene 4 | 第85-86页 |
| ·:Preparation of PEGylated gold nanoparticle | 第86页 |
| ·:Preparation of Fc-GNP via click reaction | 第86-87页 |
| ·:Self-assembled monolayer formation | 第87页 |
| ·:Monitoring non-specific adsorption by CV | 第87页 |
| ·:Monitoring non-specific adsorption by SPR | 第87-88页 |
| ·:Monitoring non-specific adsorption by FTIR | 第88页 |
| ·:RESULTS AND DISCUSSION | 第88-99页 |
| ·:Synthesis of materials used for gold nanoparticle preparation | 第88-89页 |
| ·:Preparation of PEGylated gold nanoparticle | 第89-91页 |
| ·:Preparation of ferrocene PEGylated gold nanoparticle | 第91-92页 |
| ·:Adsorption of Fc-GNP to bare electrodes | 第92-94页 |
| ·:Adsorption of Fc-GNP to thiol-modified gold electrode | 第94-95页 |
| ·:Determination of electrode surface coverage and diffusion coefficient | 第95-96页 |
| ·:Assessment of the non-specific adsorption of Fc-GNP to BSA using CV | 第96-97页 |
| ·:Assessment of the non-specific adsorption of Fc-GNP to BSA using SPR and FTIR | 第97-99页 |
| ·:SUMMARY | 第99-100页 |
| REFERENCES | 第100-103页 |
| CHAPTER FIVE:GOLD NANOPARTICLE-CATALYZED SONOGASHIRA COUPLINGREACTION | 第103-120页 |
| ·:BACKGROUND | 第103-106页 |
| ·:EXPERIMENTAL | 第106-108页 |
| ·:General procedure | 第106-107页 |
| ·:Preparation of gold nanoparticles | 第107页 |
| ·:Preparation of catalysts | 第107页 |
| ·:Testing of the catalysts | 第107-108页 |
| ·:Transmission electron microscopy(TEM) | 第108页 |
| ·:RESULTS AND DISCUSSION | 第108-116页 |
| ·:Preparation of gold nanoparticle catalysts | 第108-110页 |
| ·:Estimation of the yield of diphenylacetylene by gas chromatography | 第110-111页 |
| ·:Shape-dependent gold nanocatalysis of Sonogashira reaction | 第111-113页 |
| ·:Size-dependent gold nanocatalysis of Sonogashira reaction | 第113-114页 |
| ·:Gold nanocatalysis of Sonogashira coupling:The effect of temperature and time course of the reaction | 第114-116页 |
| ·:SUMMARY | 第116-117页 |
| REFERENCES | 第117-120页 |
| CHAPTER SIX:GOLD NANOPARTICLE-CATALYZED CYCLOHEXANE OXIDATION | 第120-142页 |
| ·:BACKGROUND | 第120-122页 |
| ·:EXPERIMENTAL | 第122-123页 |
| ·:General procedure | 第122页 |
| ·:Preparation of gold nanoparticle catalysts | 第122-123页 |
| ·:Testing of the catalysts | 第123页 |
| ·:RESULTS AND DISCUSSION | 第123-137页 |
| ·:Preparation of gold nanocatalysts | 第123-124页 |
| ·:Oxidation under conventional heating | 第124-128页 |
| ·:Oxidation under sonication | 第128-130页 |
| ·:Oxidation under microwave irradiation | 第130-137页 |
| ·:SUMMARY | 第137-138页 |
| REFERENCES | 第138-142页 |
| CONCLUSION | 第142-143页 |
| PUBLICATIONS | 第143-144页 |
| ACKNOWLEDGMENT | 第144页 |
