| LIST OF ABBREVIATIONS | 第10-12页 |
| 摘要 | 第12-16页 |
| Abstract | 第16-19页 |
| Chapter 1 | 第20-50页 |
| 1.1 Introduction | 第21-24页 |
| 1.2 Materials and Methods | 第24-28页 |
| 1.2.1 Animals | 第24页 |
| 1.2.2 Experiment equipment | 第24页 |
| 1.2.3 Anesthesia and surgical procedures | 第24-25页 |
| 1.2.4 Electrophysiological recordings | 第25页 |
| 1.2.5 Sensory stimulation | 第25-26页 |
| 1.2.6 Drug administration | 第26-27页 |
| 1.2.7 Statistical analysis | 第27-28页 |
| 1.3 Results | 第28-40页 |
| 1.3.1 Facial air-puff stimulation-evoked distinct 打el过 potentials cerebellar ML,PCL and GCL | 第28-29页 |
| 1.3.2 Dynamic properties of facial sti扣ulatio凸-evoked fi加 potentials in 化e GCL | 第29-32页 |
| 1.3.3 Dynamic properti的 of 化cial stimulation-evoked Held potentials in 化e ML | 第32-35页 |
| 1.3.4 Frequency properties of facial stimulation-evoked extracellular responses inPCs | 第35-37页 |
| 1.3.5 Effect of GABAa receptor anl:agoiiist on facial stimulation train evokedresponses in PCs | 第37-40页 |
| 1.4 Discussion | 第40-44页 |
| 1.4.1 Cerebellar GCL expresses high frequency and high fidelity propertiesduring 化e sensory informatio田 promsing | 第40-41页 |
| 1.4.2 Cerebellar coWical molecular layer acts as a low-pass 巧Iter during thesensory information processing in cerebellar cortex. | 第41-42页 |
| 1.4.3 Cerebdlar PCs genera化 sensory rela化d output is limited to low frequencysensory in化rmation inputs | 第42-44页 |
| 1.5 Conclusions | 第44-45页 |
| 1.6 References | 第45-50页 |
| Chapter2 | 第50-77页 |
| 2.1 Introduction | 第51-54页 |
| 2.2 Materials and Methods | 第54-57页 |
| 2.2.1 Animals | 第54页 |
| 2.2.2 Experiment equipment | 第54页 |
| 2.2.3 Anesthesia and surgical procedures | 第54-55页 |
| 2.2.4 In vivo cell-attached recordings | 第55页 |
| 2.2.5 Sensory stimulation | 第55-56页 |
| 2.2.6 Chemicals | 第56页 |
| 2.2.7 Statistical analysis | 第56-57页 |
| 2.3 Results | 第57-67页 |
| 2.3.1 1 Hz facial stimulation induced LTD of GABAergic transmission at PCs inmouse cerebellar cortex | 第57-60页 |
| 2.3.2 1 Hz facial stimulation induced LTD of GABAergic transmission at PCs, butwithout significant change the properties of sensory-evoked Ksponse in MLIs | 第60-62页 |
| 2.3.3 Induction of MLI-PC GABAergic LTD required activation of CBl receptors "55 | 第62-64页 |
| 2.3.4 Induction of MLI-PC GABAergic LTD required activation of NMD A receptors,but not mGluRl | 第64-67页 |
| 2.4 Discussion | 第67-71页 |
| 2.4.1 Repeated facial stimulation induced LTD of GABAergic transmission atMLI-PC synapses in vivo in mice | 第67-68页 |
| 2.4.2 Possible mechanisms of the sensory induced MLI-PC GABAergic LTD invivo in mice | 第68-71页 |
| 2.5 Conclusion | 第71-72页 |
| 2.6 References | 第72-77页 |
| Review | 第77-88页 |
| 1. Introdudion | 第77页 |
| 2. The functional organization of cerebellum | 第77-79页 |
| 2.1 Structure of cerebellum | 第77-78页 |
| 2.2 Functioii of cerebellum | 第78-79页 |
| 3. Cerebellar microcircuit and information transmission | 第79-81页 |
| 3.1 Consists of cerebellar microdrcu扣 | 第79-80页 |
| 3.2 Information proc议sing in cerebellar cortex | 第80-81页 |
| 4. Synaptic plasticity in cerebellar cortical neurons | 第81-88页 |
| 4.1 Mossy 巧ber-granule cell synaptic plasticity | 第81-82页 |
| 4.2 Parallel fiber-Purkinje cell (PF-PC) synaptic plasticity | 第82-85页 |
| 4.2.1 Postsynaptic PF-PC LTD and LTP | 第82-84页 |
| 4.2.2 Presynaptic PF-PC LTD and LTP | 第84-85页 |
| 4.3 PF-MLI 巧naptic plasticity | 第85-86页 |
| 4.4 MLI - PC 巧naj)tic plasticity | 第86-87页 |
| In conclusion | 第87-88页 |
| Review references | 第88-101页 |
| Publication | 第101-103页 |
| 致谢 | 第103页 |
