| Acknowledgements | 第1-7页 |
| 中文摘要 | 第7-9页 |
| ABSTRACT | 第9-16页 |
| CHAPTER Ⅰ - Literature Review | 第16-38页 |
| 1. Disease resistance and immunity | 第17-26页 |
| ·Defining disease | 第17-18页 |
| ·The mechanism of resistance | 第18-22页 |
| ·The genetic basis of disease resistance | 第22-26页 |
| 2. The breeding of disease resistant strains | 第26-31页 |
| ·Direct selection | 第28页 |
| ·Indirect selection | 第28-30页 |
| ·Transgenic method | 第30-31页 |
| ·Marker assisted selection | 第31页 |
| 3. Progress in disease resistant breeding | 第31-36页 |
| ·Progress in livestock and poultry disease resistant breeding | 第32-34页 |
| ·Aquatic animal disease resistance breeding research | 第34-36页 |
| 4. Challenges and opportunities | 第36-37页 |
| ·Challenges | 第36页 |
| ·Opportunities | 第36-37页 |
| 5. Objectives and Significance of the study | 第37-38页 |
| CHAPTER Ⅱ - CfPGRP gene polymorphism and its association with disease resistance/susceptibility in scallop | 第38-78页 |
| Section Ⅰ - Introduction | 第38-40页 |
| Section Ⅱ - Materials and methods | 第40-61页 |
| 1. Chemicals and equipments | 第40-41页 |
| 2 Preparation of reagents and culture media | 第41-43页 |
| 3 Experimental methods | 第43-61页 |
| ·Scallops and Bacterial challenge | 第43-44页 |
| ·Extraction of genomic DNA | 第44-61页 |
| Section Ⅲ - Experimental results | 第61-75页 |
| 1 The scallop Susceptible and resistant stocks | 第61页 |
| 2 The features and structural organization CfPGRP genomic DNA | 第61-66页 |
| 3 Polymorphisms of PGRP domain region of CfPGRP-S151 | 第66-68页 |
| 4 The association between CG/TA polymorphism and disease resistance/susceptibility | 第68-71页 |
| 5 In vitro Functional capabilities of protein variants | 第71-75页 |
| Section Ⅳ - Discussion and Conclusion | 第75-78页 |
| CHAPTER Ⅲ - CfLGBP gene polymorphism and its association with disease resistance/susceptibility in scallop | 第78-101页 |
| Section Ⅰ - Introduction | 第78-80页 |
| Section Ⅱ - Materials and methods | 第80-85页 |
| 1 Chemical reagents and equipments | 第80页 |
| 2 Reagent preparations | 第80页 |
| 3 Experimental methods | 第80-85页 |
| Section Ⅲ - Experimental results | 第85-98页 |
| 1 The scallop Susceptible and resistant stocks | 第85页 |
| 2 CfLGBP genomic DNA structural organization | 第85-90页 |
| 3 The polymorphisms in the LPS and glucanase binding domain of CfLGBP domain | 第90-92页 |
| 4 Association of SNP +7679 G-A with disease resistance/susceptibility of scallops | 第92-94页 |
| 5 Invitro Functional assays for protein variants | 第94-98页 |
| Section Ⅳ - Discussion and Conclusion | 第98-101页 |
| CHAPTER Ⅳ - Bay scallop Serine protease inhibitor, Defensin gene polymorphism and its association with disease resistance/susceptibility in scallop | 第101-123页 |
| Section Ⅰ - Introduction | 第101-103页 |
| Section Ⅱ - Materials and methods | 第103-108页 |
| 1 Chemical reagents and equipments | 第103页 |
| 2 Reagent preparations | 第103页 |
| 3 Experimental methods | 第103-108页 |
| Section Ⅲ - Experimental results | 第108-117页 |
| 1 Susceptible and resistant bay scallop stocks | 第108页 |
| 2 AiSPI, AiDef domain genomic DNA structural organization | 第108-111页 |
| 3 AiSPI gene polymorphism | 第111-112页 |
| 4 Association of SNP +536, +1312 with disease resistance/susceptibility of scallops | 第112-116页 |
| 5 In vitro functional capability of protein variants | 第116-117页 |
| Section Ⅲ – Discussion and Conclusion | 第117-122页 |
| CHAPTER Ⅴ – Conclusion | 第122-123页 |
| References | 第123-144页 |
| Publications | 第144-145页 |
