| 摘要 | 第9-11页 |
| Abstract | 第11-13页 |
| 1 Introduction | 第14-36页 |
| 1.1 Reactive oxygen species and oxidative stress | 第15-24页 |
| 1.1.1 Reactive oxygen species generation | 第15-17页 |
| 1.1.2 Antioxidant defense | 第17-18页 |
| 1.1.3 Oxidative stress | 第18-19页 |
| 1.1.4 Oxidative stress in chicken | 第19-22页 |
| 1.1.5 Oxidative stress and immuno-competence | 第22-24页 |
| 1.2 Inflammatory cytokines | 第24-28页 |
| 1.2.1 Monocyte Chemoattractant Protein (MCP-1) | 第25页 |
| 1.2.2 Interleukenes-6 (IL-6) | 第25-27页 |
| 1.2.3 Tumor necrosis factor-alpha (TNF-α) | 第27-28页 |
| 1.3 Insulin signaling pathway | 第28-31页 |
| 1.3.1 The structure and mediators of PI3K/ PKB signal transduction pathway | 第29-30页 |
| 1.3.2 The molecular mechanism of PI3K/ PKB activation | 第30-31页 |
| 1.4 Effects of streptozotocin on blood insulin | 第31页 |
| 1.5 Physicochemical properties, sources and biological functions of quercetin | 第31-34页 |
| 1.5.1 Physicochemical properties of quercetin | 第31-32页 |
| 1.5.2 Sources and biological functions of quercetin | 第32-34页 |
| 1.6 Purpose and significance | 第34-36页 |
| 2 Materials and Methods | 第36-44页 |
| 2.1 Materials | 第36页 |
| 2.2 Experimental design and experimental diets | 第36-37页 |
| 2.2.1 Experimental design | 第36页 |
| 2.2.2 Experimental diets | 第36-37页 |
| 2.3 Feeding and management | 第37页 |
| 2.4 Determination of indexes | 第37-42页 |
| 2.4.1 Growth performance | 第37-38页 |
| 2.4.2 Slaughter performance | 第38页 |
| 2.4.3 Blood biochemical indicators | 第38-39页 |
| 2.4.4 Enzymic antioxidant assay | 第39-40页 |
| 2.4.5 Inflammatory cytokine assay | 第40页 |
| 2.4.6 Molecular indexes | 第40-42页 |
| 2.5 Data analysis | 第42-44页 |
| 3 Results and Analysis | 第44-54页 |
| 3.1 Effects of quercetin on fasting blood glucose and insulin in hyperglycemic AA broilersinduced by streptozotocin | 第44-45页 |
| 3.2 Effects of quercetin on serum lipid profile in hyperglycemic AA broilers induced bystreptozotocin | 第45页 |
| 3.3 Effects of quercetin on growth performance in hyperglycemic AA broilers induced bystreptozotocin | 第45-46页 |
| 3.4 Effects of quercetin on slaughter performance in hyperglycemic AA broilers induced bystreptozotocin | 第46-47页 |
| 3.5 Effects of quercetin on serum biochemical indicators in hyperglycemic AA broilers inducedby streptozotocin | 第47-48页 |
| 3.6 Effects of quercetin on nitric oxide levels in hyperglycemic AA broilers induced bystreptozotocin | 第48-49页 |
| 3.7 Effects of quercetin on lipid peroxidation in hyperglycemic AA broilers induced bystreptozotocin | 第49页 |
| 3.8 Effects of quercetin on oxidative stress markers in hyperglycemic AA broilers induced bystreptozotocin | 第49-51页 |
| 3.9 Effects of quercetin on inflammatory cytokine levels in hyperglycemic AA broilers inducedby streptozotocin | 第51-52页 |
| 3.10 Effects of quercetin on the PI3K/PKB insulin signaling pathway in hyperglycemic AAbroilers induced by streptozotocin | 第52-54页 |
| 4 Discussion | 第54-68页 |
| 4.1 Effects of quercetin on fasting blood glucose and insulin in hyperglycemic AA broilersinduced by streptozotocin | 第54-55页 |
| 4.2 Effects of quercetin on lipid profile in AA broilers with STZ | 第55-57页 |
| 4.3 Effects of quercetin on growth performance and slaughter performance in AA broilers with STZ | 第57-59页 |
| 4.4 Effects of quercetin on serum biochemical indicators in hyperglycemic AA broilers with STZ | 第59页 |
| 4.5 Effects of quercetin on oxidative stress markers in hyperglycemic AA broilers with STZ | 第59-63页 |
| 4.6 Effects of quercetin on inflammatory cytokine levels in hyperglycemic AA broilers with STZ | 第63-65页 |
| 4.7 Effects of quercetin on the PI3K/PKB insulin signaling pathway in AA broilers with STZ | 第65-68页 |
| 5 Conclusion | 第68-69页 |
| Acknowledgement | 第69-70页 |
| References | 第70-98页 |
| Papers published in the period of Ph.D education | 第98-99页 |
