| List of contents | 第1-8页 |
| Abbreviations | 第8-11页 |
| Abstract | 第11-13页 |
| 摘要 | 第13-15页 |
| Chapter one: Introduction and aims of the study | 第15-19页 |
| ·Introduction | 第15-18页 |
| ·Aims of the study | 第18-19页 |
| Chapter two: Literature review | 第19-50页 |
| ·The odontogenic lesions | 第19-35页 |
| ·Dentegerous cyst | 第20-23页 |
| ·Keratocyst odontogenic tumor | 第23-28页 |
| ·Ameloblastoma | 第28-35页 |
| ·Human papillomavirus(HPV) | 第35-44页 |
| ·Ki-67 protein | 第44-46页 |
| ·Cyclooxygenase-2(COX-2) | 第46-50页 |
| Chapter three: Materials and Methods | 第50-64页 |
| ·Study design and selection criteria | 第50-52页 |
| ·Retrieving and collection of the FFPE and frozen tissue samples | 第52-54页 |
| ·Immunohistochemical analysis | 第54-56页 |
| ·Immunohistochemical procedures | 第54-55页 |
| ·Assessment of immunohistochemically stained sections | 第55-56页 |
| ·Genomic DNA extaction,PCR assay,and Gel electrophoresis | 第56-63页 |
| ·DNA extraction | 第56-58页 |
| ·a DNA extraction from the FFPE samples | 第56-57页 |
| ·b DNA extraction from frozen tissue samples | 第57-58页 |
| ·Assessing the concentrations and evaluating the quality of the extracted genomic DNA | 第58-60页 |
| ·PCR assay | 第60-62页 |
| ·Gel electrophoresis and the detection of the amplification products | 第62-63页 |
| ·Statistical analysis | 第63-64页 |
| Chapter four: Results | 第64-77页 |
| ·Investigations of HPV in dentigerous cysts, keratocystic odontogenic tumors, and ameloblastomas | 第64-70页 |
| ·a PCR analysis of HPV-DNA | 第64-67页 |
| ·b Immunohistochemical expression of HPV-L1 protein and its relation to HPV-DNA analysis | 第67-70页 |
| ·Expression of Ki-67 in dentigerous cysts, keratocystic odontogenic tumors, and ameloblastomas | 第70-73页 |
| ·Expression of COX-2 in dentigerous cysts, keratocystic odontogenic tumors, and ameloblastomas | 第73-76页 |
| ·Correlations of HPV (HPV-DNA, HPV-L1), Ki-67, and COX-2 proteins expression in each of the studied lesions | 第76-77页 |
| Chapter five: Discussion | 第77-95页 |
| ·Presence of HPV in dentigerous cyst, keratocystic odontogenic tumor, and ameloblastoma | 第77-84页 |
| ·Expression of Ki-67 protein in dentigerous cyst, keratocystic odontogenic tumor, and ameloblastoma | 第84-86页 |
| ·Expression of COX-2 in dentigerous cyst, keratocystic odontogenic tumor, and ameloblastoma | 第86-90页 |
| ·Correlations of HPV with COX-2 and Ki-67 in keratocystic odontogenic tumor | 第90-92页 |
| ·Correlation of COX-2 and Ki-67 proteins in ameloblastoma | 第92-95页 |
| Chapter six: Conclusions and Suggestions for further studies | 第95-97页 |
| ·Conclusions | 第95-96页 |
| ·Suggestions for Further Studies | 第96-97页 |
| References | 第97-132页 |
| Acknowledgments | 第132-133页 |
