| Abstract | 第7页 |
| Introduction | 第8-9页 |
| Chapter 1 Hepatoprotective effect of Salvia miltiorrhiza and scutellaria baicalensis on hepatic injury in mice or rats | 第9-31页 |
| 1 Materials | 第9-10页 |
| 1.1 Plant material | 第9页 |
| 1.1.1 Salvia miltiorrhiza extract | 第9页 |
| 1.1.2 Scutellaria baicalensis extract | 第9页 |
| 1.2 Reagents and apparatus | 第9页 |
| 1.3 Animals | 第9-10页 |
| 2 Methods | 第10-13页 |
| 2.1 The effect of the ethanol extract from Salvia miltiorrhiza on D-GalN/LPS-induced liver injury, in mice | 第10页 |
| 2.2 The effect of the extract from Salvia miltiorrhiza on D-GalN-induced liver injuryin mice | 第10-11页 |
| 2.3 The effect of the ethanol extract from Salvia miltiorrhiza on CCL_4-induced liver injury in rats | 第11页 |
| 2.4 The effect of the extract from Scutellara baicalensis on D-GalN/LPS-induced liver injury in mice | 第11页 |
| 2.5 The effect of the extract from Scutellaria baicalensis on D-GalN-induced liver injury in mice | 第11-12页 |
| 2.6 Histology | 第12页 |
| 2.7 Statistical analysis | 第12-13页 |
| 3 Results | 第13-29页 |
| 3.1 The effect of the ethanol extract from Salvia miltiorrhiza suppressed mice serum biochemical parameters after D-GalN/LPS administration | 第13-15页 |
| 3.2 The extract from Salvia miltiorrhiza suppressed mice serum biochemical parameters after D-GalN administration | 第15-17页 |
| 3.3 The ethanol extract from Salvia miltiorrhiza suppressed rats serum biochemical parameters after CCL_4 administration | 第17-19页 |
| 3.4 The extract from Scutellaria baicalensis suppressed mice serum biochemical parameters after D-GaIN/LPS administration | 第19-21页 |
| 3.5 The extract from Scutellaria baicalensis suppressed mice serum biochemical parameters after D-GalN administration | 第21-23页 |
| 3.6 Histology | 第23-29页 |
| 3.6.1 The effect of the 55% ethanol extract of Salvia miltiorrhiza on histological changes in the mice liver | 第23页 |
| 3.6.2 The effect of the 55% ethanol extract of Salvia miltiorrhiza on histological changes in the rats liver | 第23-24页 |
| 3.6.3 The effect of the extract of Scutellaria baicalensis on histological changes in the mice liver | 第24-29页 |
| 4 Discusion | 第29-31页 |
| Chapter 2 Hepatoprotective effect of Sedum sarmentosum on hepatic injury in mice | 第31-47页 |
| 1 Materials | 第31-32页 |
| 1.1 Plant material | 第31页 |
| 1.1.1 Preparation of Sedum sarmentosum thick juice | 第31页 |
| 1.1.2 preparation of Sedum sarmentosum aqueous extract | 第31页 |
| 1.1.3 preparation of Sedum sarmentosum ethanol extract | 第31页 |
| 1.2 Reagent | 第31-32页 |
| 1.3 Animals | 第32页 |
| 2 Methods | 第32-35页 |
| 2.1 CPC suppressed Lethality in mice with GalN/LPS-induced liver injury | 第32页 |
| 2.2 The effect of the CPC on D-GalN/LPS-induced liver injury in mice | 第32-33页 |
| 2.3 The effect of the CPC on D-GalN/TNF-α-induced liver injury in mice | 第33页 |
| 2.4 Preparation of Nuclear Extracts and Electrophoretic Mobility Shift Assay (EMSA) | 第33-34页 |
| 2.5 Liver DNA extraction and detection of DNA fragmentation | 第34页 |
| 2.6 Histology | 第34页 |
| 2.7 Statistical analysis | 第34-35页 |
| 3 Results | 第35-45页 |
| 3.1 CPC suppressed Lethality in mice with GalN/LPS-Induced liver injury | 第35-36页 |
| 3.2 The extract of CPC suppressed mice serum biochemical parameters after D-GalN/LPS administration | 第36-39页 |
| 3.3 The extract of CPC suppressed mice serum biochemical parameters after D-GalN/TNF-α administration | 第39-41页 |
| 3.4 CPC suppressed Transcription Factor NF-KB Activation in mice with D-GalN/LPS-Induced liver iinjury | 第41页 |
| 3.5 The protective effect of CPC on the DNA fragmentation of the mice liver in D-GalN/LPS-induced liver injury | 第41-42页 |
| 3.6 CPC reduced hepatocyte apoptosis in mice with D-GalN/LPS-induced liver injury | 第42-45页 |
| 4 Discussion | 第45-47页 |
| References | 第47-50页 |
| Review | 第50-59页 |
| Acknowledgment | 第59页 |
