| DECLARATION AND COPYRIGHT | 第1-5页 |
| ABSTRACT | 第5-7页 |
| 摘要 | 第7-8页 |
| TABLE OF CONTENTS | 第8-13页 |
| LIST OF FIGURES | 第13-14页 |
| LIST OF TABLES | 第14-15页 |
| SYMBOLS AND ABBREVIATIONS | 第15-16页 |
| Chapter 1 Introduction | 第16-28页 |
| ·Aripiprazole | 第16-17页 |
| ·Schizophrenia | 第17-18页 |
| ·Dopamine Hypothesis of Schizophrenia and Partial Agonist Concept | 第18-23页 |
| ·Antipsychotic Drugs | 第23-28页 |
| ·Typical Antipsychotic Drugs | 第24-26页 |
| ·Atypical Antipsychotic Drugs | 第26-28页 |
| Chapter 2 Determination of Synthesis Route for Aripiprazole | 第28-37页 |
| ·Review of the Synthesis of Aripiprazole | 第28-30页 |
| ·Review of the Synthesis of Carbostyril Compound | 第30-31页 |
| ·Review of the Synthesis of Phenylpiperazine Compound | 第31-33页 |
| ·Problem Statement | 第33-34页 |
| ·Objectives | 第34页 |
| ·Significance of the Study | 第34-35页 |
| ·Organization of the Dissertation | 第35-37页 |
| Chapter 3: Results and Discussions | 第37-48页 |
| ·Carbostyril Compound | 第37-42页 |
| ·Synthesis of Cinnamoyl Chloride | 第37-39页 |
| ·Synthesis of 3-Hydroxycinnamanilide | 第39-40页 |
| ·Synthesis of 7-Hydroxyquinolinone | 第40-41页 |
| ·Synthesis of 7-Hydroxy-3, 4-dihydro-2-(1H)-quinolinone | 第41-42页 |
| ·Synthesis of Phenylpiperazine Compound | 第42-47页 |
| ·Synthesis of 1,2-Dichloro-3-Iodobenzene | 第42-43页 |
| ·Synthesis of 2, 3-Dichlorophenylpiperazine | 第43-47页 |
| ·Synthesis of Aripiprazole | 第47-48页 |
| Chapter 4 Conclusion and Recommendations | 第48-50页 |
| ·Conclusion | 第48页 |
| ·Recommendations | 第48-50页 |
| Chapter 5 Experimental Section | 第50-58页 |
| ·Materials | 第50-51页 |
| ·Equipments and Apparatus | 第51-52页 |
| ·Experimental Procedure | 第52-58页 |
| ·Preparation of Cinnamoyl Chloride | 第52-53页 |
| ·Preparation of 3-Hydroxycinnamanilide | 第53页 |
| ·Preparation of 7-Hydroxyquinolinone | 第53-54页 |
| ·Preparation of 7-Hydroxy-3,4-dihydro-2-(1H)-quinolinone | 第54页 |
| ·Preparation of 1,2-Dichloro-3-Iodobenzene | 第54-55页 |
| ·Preparation of 2, 3-Dichlorophenylpiperazine | 第55-56页 |
| ·Preparation of 7-(4-chlorobutoxy)-3,4-dihydro-2-(1H)-quinolinone | 第56页 |
| ·Preparation of Aripiprazole | 第56-58页 |
| REFERENCES | 第58-62页 |
| APPENNDICES | 第62-66页 |
| Appendix 1: ~1H-NMR for 7-Hydroxyquinolinone | 第62-63页 |
| Appendix 2: ~1H-NMR for 7-hydroxy-3, 4-dihydro-2-(1H)-quinolinone | 第63-64页 |
| Appendix 3: ~1H-NMR for 2,3-Dichlorophenylpiperazine | 第64-65页 |
| Appendix 4: ~1H-NMR for Aripiprazole | 第65-66页 |
| ACKNOWLEDGEMENTS | 第66-68页 |
| DEDICATION | 第68-69页 |
| PUBLISHED PAPER | 第69-70页 |
| AUTHOR RESUME | 第70-71页 |
| SUPERVISOR'S RESUMES | 第71-74页 |
