| 作者简历 | 第6-7页 |
| 摘要 | 第7-10页 |
| abstract | 第10-14页 |
| Chapter 1 Introduction | 第18-32页 |
| 1.1 Overview of antibiotics | 第18-19页 |
| 1.2 Source and distribution of antibiotics | 第19-25页 |
| 1.2.1 Source of antibiotics in the aquatic environment | 第19-21页 |
| 1.2.2 Distribution of antibiotics in surface water and groundwater | 第21-25页 |
| 1.3 Antibiotics migration from surface water to groundwater | 第25-26页 |
| 1.4 Ecological risk and hazard of antibiotics in aquatic ecosystem | 第26-28页 |
| 1.5 Sites description | 第28-30页 |
| 1.5.1 Ozark Highland in central USA | 第28-29页 |
| 1.5.2 Jianghan Plain in central China | 第29-30页 |
| 1.6 Objectives and innovations | 第30-32页 |
| 1.6.1 Objectives | 第30-31页 |
| 1.6.2 Innovations | 第31-32页 |
| Chapter 2 Occurrence and Sources of Antibiotics in the aquaticenvironment: a case study in Ozark Highlands, central USA | 第32-45页 |
| 2.1 Introduction | 第32-33页 |
| 2.2 Materials and methods | 第33-37页 |
| 2.2.1 Site description and sampling | 第33-34页 |
| 2.2.2 Standards and chemicals | 第34-35页 |
| 2.2.3 Sample pretreatment and analysis | 第35-36页 |
| 2.2.4 Quantification and method validation | 第36-37页 |
| 2.2.5 Statistical analysis | 第37页 |
| 2.3 Results and discussion | 第37-44页 |
| 2.3.1 Occurrence of antibiotics in surface water | 第37-41页 |
| 2.3.2 Spatial and temporal patterns of antibiotics in surface waters | 第41-44页 |
| 2.4 Conclusions | 第44-45页 |
| Chapter 3 Occurrence and transport of antibiotics in surfacewater-groundwater systems: a case study in Jianghan Plain, central China | 第45-75页 |
| 3.1 Introduction | 第45-46页 |
| 3.2 Materials and methods | 第46-54页 |
| 3.2.1 Site description and sampling | 第46-48页 |
| 3.2.2 Standards and chemicals | 第48-49页 |
| 3.2.3 Hydrochemical analysis | 第49页 |
| 3.2.4 Extraction and analysis of antibiotics | 第49-52页 |
| 3.2.5 Quantification and method validation | 第52-54页 |
| 3.2.6 Statistical analysis | 第54页 |
| 3.3 Results and discussion | 第54-74页 |
| 3.3.1 Hydrochemistry | 第54-59页 |
| 3.3.2 Occurrence and seasonal variations of antibiotics in the aquaticenvironment | 第59-64页 |
| 3.3.3 Spatial patterns of antibiotics in the aquatic environment | 第64-68页 |
| 3.3.4 The effect of surface water-groundwater interactions on antibioticsconcentration in groundwater | 第68-74页 |
| 3.4 Conclusions | 第74-75页 |
| Chapter 4 Hazard and risk assessment of antibiotics in the aquaticenvironment | 第75-91页 |
| 4.1 Introduction | 第75-76页 |
| 4.2 Methods | 第76-80页 |
| 4.2.1 Resistance hazard assessment | 第76-77页 |
| 4.2.2 Risk assessment | 第77-80页 |
| 4.3 Results and discussion | 第80-89页 |
| 4.3.1 Resistance hazards of antibiotics in the aquatic environment | 第80-83页 |
| 4.3.2 Environmental risks of the individual pharmaceuticals | 第83-87页 |
| 4.3.3 Environmental risks of antibiotics mixtures in the aquatic environment | 第87-89页 |
| 4.4 Conclusions | 第89-91页 |
| Chapter 5 Toxicity of antibiotics on green algae | 第91-108页 |
| 5.1 Introduction | 第91-92页 |
| 5.2 Materials and methods | 第92-97页 |
| 5.2.1 Chemicals | 第92-93页 |
| 5.2.2 Algal culture | 第93-94页 |
| 5.2.3 Procedure for the growth inhibition test | 第94-95页 |
| 5.2.4 Photosynthetic pigment content | 第95-96页 |
| 5.2.5 Quality assurance and quality control | 第96-97页 |
| 5.2.6 Statistical analysis | 第97页 |
| 5.3 Results and discussion | 第97-106页 |
| 5.3.1 Toxicity of individual antibiotics based on P. subcapitata growth | 第97-100页 |
| 5.3.2 Toxicity of mixture based on P. subcapitata growth | 第100-104页 |
| 5.3.3 Toxic effects of antibiotics on pigment synthesis | 第104-106页 |
| 5.4 Conclusions | 第106-108页 |
| Chapter 6 Conclusions and suggestions | 第108-112页 |
| 6.1 Conclusions | 第108-110页 |
| 6.2 Suggestions | 第110-112页 |
| Acknowledgement | 第112-114页 |
| References | 第114-126页 |
