| List of contents | 第1-9页 |
| Abbreviations | 第9-10页 |
| Chapter 1 Literature | 第10-30页 |
| ·Characteristic of Depression | 第10-13页 |
| ·Stress and Depression | 第13-14页 |
| ·Animal behavior and Chronic Stress | 第14-15页 |
| ·The role of Stress hormone and Depression | 第15-21页 |
| ·The relation between Thyroid function and Depression | 第21-23页 |
| ·Adenosine Receptors and Depression | 第23-26页 |
| ·Homeostatic modulatory role of adenosine | 第24页 |
| ·Neuromodulatory role of adenosine | 第24-26页 |
| ·Adenosine and Depression | 第26页 |
| ·The Habenular–Raphe pathway and Depression | 第26-29页 |
| ·Blood Pressure, Heart rate and Depression | 第29-30页 |
| Chapter 2 Materials and Methods | 第30-47页 |
| ·Animals Preparation | 第30页 |
| ·Drugs | 第30-33页 |
| ·Drugs and chemicals | 第31-32页 |
| ·Instruments | 第32-33页 |
| ·Chronic Unpredictable Mild Stress (CUMS) | 第33页 |
| ·Behavioral Testing | 第33-34页 |
| ·Open field test (OFT) | 第33-34页 |
| ·Forced swimming test (FST) | 第34页 |
| ·Cortisol, T3, T4 Assessment | 第34-40页 |
| ·Cortisol Technique | 第35-36页 |
| ·Triiodothyronine (T3) Technique | 第36-38页 |
| ·Thyroxine (T4) Technique | 第38-40页 |
| ·C-fos Technique | 第40-41页 |
| ·Blood Pressure and Heart Rate measurement | 第41页 |
| ·Experimental design | 第41-46页 |
| ·Experiment 1 | 第41-42页 |
| ·Experiment 2 | 第42-43页 |
| ·Experiment 3 | 第43-45页 |
| ·Experiment 4 | 第45-46页 |
| ·Statistical analysis | 第46-47页 |
| Chapter 3 Results | 第47-84页 |
| ·The effect of adenosine (i.p) on animal behavior induced by CUMS | 第47-56页 |
| ·Effects of CUMS procedure on animal behavior time during OFT and FST | 第47-51页 |
| ·Effects of Adenosine R-PIA on animal behavior time during OFT and FST | 第51-56页 |
| ·The effect of Adenosine (i.p) body weight change, hormonal profile, blood pressure and heart rate under CUMS procedure | 第56-62页 |
| ·Effect of R-PIA on body weight change under CUMS | 第56-57页 |
| ·Effect of R-PIA on Cortisol,T3 and T4 profiles under CUMS | 第57-60页 |
| ·Effect of R-PIA on Blood Pressure and Heart Rate under CUMS | 第60-62页 |
| ·The effect of adenosine (i.p) on animal behavior responses after Hb lesion under CUMS procedure | 第62-68页 |
| ·Open field test session | 第62-66页 |
| ·Forced swimming test session | 第66-68页 |
| ·The effect of microinjection of adenosine into the LHb and the ange in the behavioral responses and C-fos expression in the ippocampus induced by CUMS | 第68-81页 |
| ·The effect of microinjection of R-PIA agonist into the LHb and the changes in the behavioral responses produced by CUMS | 第68-80页 |
| ·The effect of microinjection of R-PIA agonist into the LHb on C-fos expression in Hippocampus induced by CUMS | 第80-81页 |
| ·Effect of microinjection of R-PIA into the LHb on the unite discharges of Dorsal Raphe neurons | 第81-84页 |
| Chapter 4 Discussion | 第84-94页 |
| ·Methodological considerations of the study | 第84-86页 |
| ·The animal model | 第84页 |
| ·Choice of Habenula and Dorsal Raphe for the chronic treatment | 第84-85页 |
| ·Choice of behavioral tests | 第85页 |
| ·Choice of adenosine for treatments | 第85-86页 |
| ·General discussion | 第86-91页 |
| ·Conclusion | 第91-94页 |
| Chapter 5 References | 第94-123页 |
| Chinese Abstract | 第123-125页 |
| English Abstract | 第125-135页 |
| Acknowledgements | 第135-136页 |
| List of original publications | 第136-137页 |
| Dedication | 第137页 |
