| 摘要 | 第3-8页 |
| abstract | 第8-9页 |
| Chapter 1 C–C bond formation via C–H activation mediated by main group and transition metals | 第14-52页 |
| 1.1 Introduction | 第14-17页 |
| 1.2 Deprotonation by organolithium reagents and formation of new C–C bonds | 第17-27页 |
| 1.2.1 Introduction of lithium reagents | 第17页 |
| 1.2.2 Deprotonation by organolithium reagents on sp C and formation of new C–C bonds | 第17-20页 |
| 1.2.3 Deprotonation by organolithium reagents on sp2 C and construction of new C–C bonds | 第20-25页 |
| 1.2.4 Deprotonation by organolithium reagents on sp3 C and construction of new C–C bonds | 第25-27页 |
| 1.3 Construction new C–C bonds through C–H activation with transition-metal catalysts in aromatic compounds | 第27-52页 |
| 1.3.1 C–H arylation | 第28-32页 |
| 1.3.2 C–H alkylation | 第32-39页 |
| 1.3.3 C–H alkenylation | 第39-46页 |
| 1.3.4 C–H acylation and carbonylation | 第46-52页 |
| Chapter 2 Review of aromatic heterocyclic compounds synthesis | 第52-88页 |
| 2.1 Introduction | 第52页 |
| 2.2 Aromatic heterocyclic compounds synthesis via transition-metal catalysts | 第52-71页 |
| 2.2.1 Ruthenium-catalyzed formation of aromatic heterocyclic compounds | 第52-55页 |
| 2.2.2 Iridium-catalyzed formation of aromatic heterocyclic compounds | 第55-58页 |
| 2.2.3 Palladium-catalyzed formation of aromatic heterocyclic compounds | 第58-67页 |
| 2.2.4 Aromatic heterocyclic compounds synthesis via other transition-metal catalysts | 第67-71页 |
| 2.3 Aromatic heterocyclic compounds synthesis without transition-metal catalysts | 第71-75页 |
| 2.3.1 Intermolecular coupling reactions without transition-metals | 第71-74页 |
| 2.3.2 Intramolecular coupling reactions without transition-metals | 第74-75页 |
| 2.4 Our study of external-ligand-free aerobic oxidation of N–and C–containing cyclic systems under Pd-catalyzed conditions | 第75-86页 |
| 2.4.1 Introduction | 第75-76页 |
| 2.4.2 Designing of project | 第76-77页 |
| 2.4.3 The results of experiments and discussions | 第77-86页 |
| 2.5 Conclusion of this chapter | 第86-88页 |
| Chapter 3 The aryl radical reaction mediated by KOt Bu | 第88-114页 |
| 3.1 Introduction of radical reactions | 第88-89页 |
| 3.2 Radical chain reactions:innate cycles from precursors to products | 第89页 |
| 3.3 Inhibitors and side reactions:the stealth chain killers | 第89-90页 |
| 3.4 Metals as catalysts | 第90-97页 |
| 3.4.1 Titanium catalysis | 第90-91页 |
| 3.4.2 Iron catalysis | 第91-92页 |
| 3.4.3 Ruthenium catalysis | 第92页 |
| 3.4.4 Cobalt catalysis | 第92-95页 |
| 3.4.5 Palladium catalysis | 第95-97页 |
| 3.5 Inorganic compounds as catalysts | 第97-100页 |
| 3.5.1 Acid as catalysts in radical reactions | 第97-98页 |
| 3.5.2 KOtBu as catalyst in radical reactions | 第98-100页 |
| 3.6 Our study of building N-and C-containing cyclic systems under KOt Bu through radical reaction | 第100-114页 |
| 3.6.1 Introduction | 第100-101页 |
| 3.6.2 Designing of project | 第101页 |
| 3.6.3 Screening reaction conditions | 第101-104页 |
| 3.6.4 The expanding of substrates | 第104-109页 |
| 3.6.5 Scale-up experiment | 第109页 |
| 3.6.6 Mechanism study | 第109-112页 |
| 3.6.7 Conclusion of this section | 第112-114页 |
| Chapter 4 Alkylation of aryl system with norbornene | 第114-130页 |
| 4.1 Introduction of norbornene | 第114-124页 |
| 4.2 Designing of project | 第124-125页 |
| 4.3 Screening reaction conditions | 第125-129页 |
| 4.4 Conclusion of this section | 第129-130页 |
| Chapter 5 Transition-metal catalyze C–H activation/annulation process | 第130-170页 |
| 5.1 Introduction | 第130页 |
| 5.2 Transition-metal catalyzed C–H activation process to construct five-membered heterocycle | 第130-150页 |
| 5.2.1 Indole syntheses | 第130-136页 |
| 5.2.2 Furan syntheses | 第136-139页 |
| 5.2.3 Methods of synthesizing isoindolone derivatives mediated by metal catalysts | 第139-142页 |
| 5.2.4 Methods of synthesizing phthalides mediated by transition metal catalysts | 第142-146页 |
| 5.2.5 Methods of synthesizing indenone derivatives mediated by transition metal catalysts | 第146-150页 |
| 5.3 Transition-metal catalyzed C–H activation process to construct six-member ring blocks | 第150-159页 |
| 5.3.1 Synthesis of isocoumarins mediated by transition-metals | 第150-152页 |
| 5.3.2 Synthesis of quinolones mediated by transition-metals | 第152-159页 |
| 5.4 Our study of building annulation indenone structure under Pd-catalyzed conditions | 第159-170页 |
| 5.4.1 Background | 第159-162页 |
| 5.4.2 Designing of project | 第162-163页 |
| 5.4.3 Process of making standard curves | 第163-164页 |
| 5.4.4 Screen reaction conditions | 第164-167页 |
| 5.4.5 Conclusion of this chapter | 第167-170页 |
| Chapter 6 Experimental parts and data | 第170-188页 |
| 6.1 Instruments and materials | 第170页 |
| 6.2 Compounds preparation of external ligand-free aerobic oxidation of N,C-containing cyclic systems under Pd-catalyzed conditions | 第170-176页 |
| 6.2.1 Preparation of N-containing heterocycle starting materials | 第170-171页 |
| 6.2.2 Preparation of N-containing heterocycle compounds under Pd-catalyzed conditions | 第171页 |
| 6.2.3 Experimental data | 第171-176页 |
| 6.3 Compounds preparation of N,C-containing cyclic systems mediated by KOt Bu | 第176-184页 |
| 6.3.1 Preparation of N-containing heterocycle starting materials | 第176页 |
| 6.3.2 Preparation of N-containing heterocycle compounds under KOt Bu conditions | 第176-182页 |
| 6.3.3 Free radical capture experiment | 第182-183页 |
| 6.3.4 Control experiment of deprotonation | 第183-184页 |
| 6.4 Merry-go-round experiment | 第184-185页 |
| 6.5 Preparation of oximes | 第185页 |
| 6.6 Preparation of2,3-diphenyl-1H-inden-1-one | 第185-188页 |
| References | 第188-210页 |
| Appendix A part of1H NMR data about some compounds | 第210-218页 |
| Publication and participation in scientific research | 第218-220页 |
| Acknowledgement | 第220页 |
