| 摘要 | 第4-6页 |
| Abstract | 第6-7页 |
| Abbreviations | 第14-15页 |
| Chapter 1 Introduction | 第15-48页 |
| 1.1 Background, Objective and the significance of the subject | 第15-17页 |
| 1.2 NIR theory and some physio-chemical principles | 第17-23页 |
| 1.2.1 Light Matter interactions, molecular vibrations and normal modes | 第18-20页 |
| 1.2.2 NIRS instrumentation and analysis modes | 第20-23页 |
| 1.2.3 NIRS analysis types (inline, on line, at line) | 第23页 |
| 1.3 The NIRS advantages and limitations | 第23-24页 |
| 1.4 NIRS Vs other vibrational spectroscopic methods | 第24-27页 |
| 1.5 NIRS and chemometrics | 第27-33页 |
| 1.5.1 Linear regression method | 第28-31页 |
| 1.5.2 Non-linear regression method | 第31-32页 |
| 1.5.3 Linear regression parameters for analytical performance estimation | 第32-33页 |
| 1.6 Applications of NIRS for qualitative and quantitative analysis | 第33-35页 |
| 1.6.1 NIRS qualifications of multicomponent systems | 第33-34页 |
| 1.6.2 NIRS quantifications of multicomponent systems | 第34-35页 |
| 1.7 Applications of NIRS for monitoring of drug delivery systems | 第35-38页 |
| 1.8 NIRS extraction of calibration and validation model process | 第38-40页 |
| 1.9 The stimuli controlled delivery systems | 第40-43页 |
| 1.9.1 p H responsive DDS | 第40-41页 |
| 1.9.2 Light responsive DDS | 第41-43页 |
| 1.10 Main research content of the subject | 第43-44页 |
| 1.11 Thesis organization | 第44-48页 |
| Chapter 2 Experimental Materials and Methods | 第48-77页 |
| 2.1 Experimental materials and instruments | 第48-51页 |
| 2.1.1 Experimental materials | 第48-49页 |
| 2.1.2 Experimental instruments | 第49-50页 |
| 2.1.3 Model drug used in our designed DDS | 第50-51页 |
| 2.2 Preparation of experimental materials | 第51-57页 |
| 2.2.1 Preparation of p H sensitive polyvinyl alcohol- doxorubicin conjugates | 第51-52页 |
| 2.2.2 Preparation of PVA-DOX ester conjugates | 第52-53页 |
| 2.2.3 p H controlled release experiment of PVA-DOX | 第53页 |
| 2.2.4 Preparation of mesoporous silica nanoparticles | 第53-54页 |
| 2.2.5 Preparation of p H and NIR responsive mesoporous silica nanoparticlesbased cargos delivery system | 第54-55页 |
| 2.2.6 Preparation of NIR responsive polydopamine nanoparticles | 第55-57页 |
| 2.3 Characterization of experimental materials | 第57-60页 |
| 2.3.1 Structural analysis of samples | 第57-58页 |
| 2.3.2 Samples analysis of surface area and porosity | 第58页 |
| 2.3.3 Morphology analysis of the samples | 第58页 |
| 2.3.4 Surface chemistry analysis | 第58-59页 |
| 2.3.5 Responsive release properties of payloads | 第59页 |
| 2.3.6 NIR induced photothermal effect | 第59-60页 |
| 2.4 Tutorials on NIR spectroscopy monitoring of cargoes delivery systems andCalibration model development process | 第60-77页 |
| 2.4.1 Samples selection and spectra acquisition | 第63-64页 |
| 2.4.2 Spectral preprocessing | 第64-70页 |
| 2.4.3 Elimination of the non-representative samples | 第70-72页 |
| 2.4.4 Extraction of calibration and validation model | 第72-77页 |
| Chapter 3 Synthesis and Evaluation of p H sensitive PVA-DOX Conjugates andMultivariate Modelling of Release | 第77-103页 |
| 3.1 Introduction | 第77-80页 |
| 3.2 Preparation of p H responsive PVA-DOX prodrug | 第80-90页 |
| 3.2.1 Characterization of chemical composition of p H responsive PVA-DOXpolymer | 第80-88页 |
| 3.2.2 DOX loading capacity on the PVA-DOX | 第88-90页 |
| 3.3 p H controlled DOX release experiment from PVA -DOX | 第90-92页 |
| 3.4 NIR monitoring of DOX release concentration in acid ic environment | 第92-101页 |
| 3.4.1 DOX samples preparation | 第92页 |
| 3.4.2 Spectra Collection | 第92-94页 |
| 3.4.3 Data processing and calibration development | 第94-101页 |
| 3.5 Brief Summary | 第101-103页 |
| Chapter 4 NIRS Monitoring of Gold Modified Polydopamine Coated Mesoporous Silica Nano-Structures with Synergetic Chemo-Photothermal Effect | 第103-137页 |
| 4.1 Introduction | 第103-106页 |
| 4.2 Characterization of the synthesized mesoporous silica nanoparticles (MSN) | 第106-108页 |
| 4.2.1 Topological analysis of MSN | 第106页 |
| 4.2.2 Structural analysis of MSN | 第106-108页 |
| 4.3 Characterization of experiment materials (MSN@DOX, MSN@DOX -PDAand MSN@DOX-PDA-Au NPs) | 第108-119页 |
| 4.3.1 Surface morphology analysis | 第108-109页 |
| 4.3.2 Surface area and porosity analysis | 第109-111页 |
| 4.3.3 Chemical composition analysis | 第111-112页 |
| 4.3.4 Drug loading amount on the synthesized nanostructures | 第112-114页 |
| 4.3.5 Surface chemical composition analysis | 第114-117页 |
| 4.3.6 Thermal analysis | 第117-119页 |
| 4.4 p H Responsive release properties of the drug | 第119-120页 |
| 4.5 Measurement of photothermal performance | 第120-125页 |
| 4.5.1 NIR irradiation induced temperature elevation | 第120-123页 |
| 4.5.2 Study of MSN@DOX-PDA-Au NPs photothermal stability | 第123页 |
| 4.5.3 The determination of the photothermal conversion efficiency ofMSN@DOX-PDA-Au NPs | 第123-125页 |
| 4.6 p H and NIR synergetic effect | 第125-127页 |
| 4.7 NIRS monitoring | 第127-135页 |
| 4.7.1 DOX samples preparation | 第127页 |
| 4.7.2 Spectral data collection | 第127-129页 |
| 4.7.3 Spectral data preprocessing | 第129-130页 |
| 4.7.4 Prediction models | 第130-135页 |
| 4.8 Brief summary | 第135-137页 |
| Chapter 5 Immobilization of Titanium Oxide on Biocompatible PolydopamineNanoparticles and NIRS Modelling of Particles Size | 第137-164页 |
| 5.1 Introduction | 第137-139页 |
| 5.2 General explanation of the designed PDNS based system | 第139-140页 |
| 5.3 Application of near infrared spectroscopy for PDNS particle s sizequantification | 第140-147页 |
| 5.3.1 Characterization of the prepared PDNS at different particles size | 第141-143页 |
| 5.3.2 Computational modelling of PDNS particles’ size using NIRS with linearregression methods | 第143-147页 |
| 5.4 Surface multi-functionalization of PDNS | 第147-156页 |
| 5.4.1 Immobilization of Ti O2 on PDNS surface | 第148-155页 |
| 5.4.2 DOX loading of PDA@Ti O2 | 第155-156页 |
| 5.5 Study of the photothermal effect | 第156-160页 |
| 5.5.1 Photothermal measurement of PDNS@Ti O2 | 第156-157页 |
| 5.5.2 Comparison PTE of PDNS with MSN@DOX-PDA-Au NPs | 第157-158页 |
| 5.5.3 p H stimuli release of DOX | 第158-159页 |
| 5.5.5 NIR stimuli release of DOX | 第159-160页 |
| 5.6 Study of the photodynamic effect | 第160-161页 |
| 5.7 Brief summary | 第161-164页 |
| Conclusions | 第164-168页 |
| The innovation of this thesis | 第166-167页 |
| Perspectives | 第167-168页 |
| References | 第168-189页 |
| List of Publications | 第189-193页 |
| Acknowledgements | 第193-194页 |
| Resume | 第194页 |
