| DEDICATION | 第5-6页 |
| ACKNOWLEDGEMENT | 第6-7页 |
| LIST OF FIGURES | 第7-8页 |
| LIST OF TABLES | 第8-9页 |
| LIST OF ABBREVIATIONS AND ACRONYMS | 第9-11页 |
| ABSTRACT | 第11-13页 |
| 摘要 | 第14-21页 |
| CHAPTER ONE INTRODUCTION AND LITERATURE REVIEW | 第21-52页 |
| 1.1. Introduction | 第21-25页 |
| 1.1.1. Problem statement and justification of the study | 第23-24页 |
| 1.1.2. Objectives of the study | 第24-25页 |
| 1.2. Literature Review | 第25-38页 |
| 1.2.1. Metabolic syndrome: definition, controversies, prevalence and clinical significance | 第25-26页 |
| 1.2.2. Pathophysiology of metabolic syndrome | 第26-28页 |
| 1.2.3. Components of metabolic syndrome | 第28-29页 |
| 1.2.4. Risk factors associated with metabolic syndrome | 第29-31页 |
| 1.2.5. Metabolic syndrome and occupation | 第31-32页 |
| 1.2.6. Metabolic syndrome and oxidative stress | 第32-33页 |
| 1.2.7. Metabolic syndrome and thyroid dysfunction | 第33-34页 |
| 1.2.8. Thyroid hormones, metabolism and oxidative stress | 第34-35页 |
| 1.2.9. Oxidative stress effects on the heart and antioxidant protection | 第35-36页 |
| 1.2.10. Oxidative stress effects on the kidney and antioxidant protection | 第36-37页 |
| 1.2.11. Oxidative stress effects on the lungs and antioxidant protection | 第37-38页 |
| 1.3. Summary of literature review and conceptual frame work of the study | 第38-40页 |
| 1.4. References | 第40-52页 |
| CHAPTER TWO PREVALENCE OF METABOLIC SYNDROME AND ITS COMPONENTS AMONG WORKERS | 第52-66页 |
| 2.1. Introduction | 第52-53页 |
| 2.2. Materials and Methods | 第53-54页 |
| 2.2.1. Study participants and research design | 第53页 |
| 2.2.2. Data collection: physical assessment, blood sample collection and preparation | 第53-54页 |
| 2.2.3. Definition of metabolic syndrome | 第54页 |
| 2.3. Statistical analysis | 第54页 |
| 2.4. Results | 第54-60页 |
| 2.4.1. Anthropometric and metabolic parameters of the study population | 第54-55页 |
| 2.4.2. Sex-specific prevalence of the number of metabolic syndrome components by age groups | 第55-56页 |
| 2.4.3. Prevalence of metabolic syndrome and its components by sex and age groups | 第56-57页 |
| 2.4.4. Association of metabolic syndrome and its components with occupation | 第57-60页 |
| 2.4.5. Prevalence of metabolic syndrome and its components in academic workers by professional positions | 第60页 |
| 2.5. Discussion | 第60-62页 |
| 2.6. Conclusion | 第62-63页 |
| 2.7. References | 第63-66页 |
| CHAPTER THREE RELATIONSHIP BETWEEN METABOLIC SYNDROME COMPONENTS AND SUBCLINICAL HYPOTHYROIDISM | 第66-83页 |
| 3.1. Introduction | 第66-67页 |
| 3.2. Materials and Methods | 第67-68页 |
| 3.2.1. Participants and research design | 第67页 |
| 3.2.2. Evaluation of thyroid function parameters | 第67-68页 |
| 3.3. Statistical analysis | 第68页 |
| 3.4. Results | 第68-74页 |
| 3.4.1. Anthropometric and metabolic parameters of study participants | 第68-69页 |
| 3.4.2. Thyroid function and metabolic syndrome components | 第69-70页 |
| 3.4.3. Metabolic parameters in euthyroidism and subclinical hypothyroidism | 第70-71页 |
| 3.4.4. Association between thyroid stimulating hormone and metabolic parameters | 第71-73页 |
| 3.4.5. Occupation and subclinical hypothyroidism | 第73-74页 |
| 3.5. Discussion | 第74-78页 |
| 3.6. Conclusion | 第78-79页 |
| 3.7. References | 第79-83页 |
| CHAPTER FOUR RELATIONSHIP BETWEEN SUBCLINICAL HYPOTHYROIDISM AND OXIDATIVE STRESS | 第83-98页 |
| 4.1. Introduction | 第83-84页 |
| 4.2. Materials and Methods | 第84-85页 |
| 4.2.1. Participants and research design | 第84页 |
| 4.2.2. Evaluation of oxidative stress markers | 第84-85页 |
| 4.3. Statistical analysis | 第85页 |
| 4.4. Results | 第85-92页 |
| 4.4.1. Lipid parameters and thyroid function | 第85-88页 |
| 4.4.2. Oxidative stress markers and thyroid function | 第88-90页 |
| 4.4.3. Oxidative stress markers and lipid parameters | 第90-92页 |
| 4.5. Discussion | 第92-94页 |
| 4.6. Conclusion | 第94-95页 |
| 4.7. References | 第95-98页 |
| CHAPTER FIVE CARDIOPROTECTIVE EFFECTS OF LIPOIC ACID, RESVERATROL AND QUERCETIN | 第98-120页 |
| 5.1. Introduction | 第98-100页 |
| 5.2. Materials and methods | 第100-103页 |
| 5.2.1. Animals and experimental design | 第100页 |
| 5.2.2. Measurement of blood pressure and heart pulse rate | 第100-101页 |
| 5.2.3. Sample collection: Blood and tissue preparations | 第101页 |
| 5.2.4. Measurement of circulating thyroid stimulating hormone and thyroid hormones ...81 | 第101页 |
| 5.2.5. Measurement of tissue oxidative stress markers | 第101-102页 |
| 5.2.6. Reverse transcription and real-time polymerase chain reaction | 第102-103页 |
| 5.3. Statistical analysis | 第103页 |
| 5.4. Results | 第103-110页 |
| 5.4.1. Changes in body weight, blood pressure, heart pulse rate and tissue weight/mice weight ratio | 第103-105页 |
| 5.4.2. Changes in thyroid stimulating hormone and thyroid hormone levels at 26 weeks.85 | 第105页 |
| 5.4.3. Changes in oxidative stress markers in the heart during the feeding period | 第105-107页 |
| 5.4.4. Changes in activities of enzymes involved in blood pressure regulation, endothelial function and cellular Ca2+transport in the heart | 第107-108页 |
| 5.4.5. Relative changes in left ventricular gene expression at 26 week of feeding | 第108-110页 |
| 5.5. Discussion | 第110-115页 |
| 5.6. Conclusion | 第115-116页 |
| 5.7. References | 第116-120页 |
| CHAPTER SIX PROTECTIVE EFFECTS OF LIPOIC ACID, RESVERATROL AND QUERCETIN ON THE KIDNEY AND LUNGS | 第120-138页 |
| 6.1. Introduction | 第120-122页 |
| 6.2. Materials and methods | 第122页 |
| 6.3. Statistical analysis | 第122页 |
| 6.4. Results | 第122-130页 |
| 6.4.1. Changes in tissue weight/mice weight ratio of the kidney and lungs | 第122-123页 |
| 6.4.2. Changes in oxidative stress markers in the kidney during the feeding period | 第123-124页 |
| 6.4.3. Changes in oxidative stress markers in the lungs during the feeding period | 第124-125页 |
| 6.4.4. Effect of diet on ACE, NOS, Na+/K+-ATPase and Ca (2+)-ATPase activity in the kidney | 第125-126页 |
| 6.4.5. Relative changes in renal expression of TRα1, DIO1, Akt, GSK3β, NrF2 and its target genes at 26 week of feeding | 第126-127页 |
| 6.4.6. Relative expression of genes involved in rennin angiotensin system, endothelial function, Ca2+ transport, fibrosis and apoptosis in the kidney | 第127-129页 |
| 6.4.7. Relative expression of genes involved in rennin angiotensin system, ATP1B1 and NF-κB in the lungs | 第129-130页 |
| 6.5. Discussion | 第130-133页 |
| 6.6. Conclusion | 第133-134页 |
| 6.7. References | 第134-138页 |
| GENERAL CONCLUSIONS AND RECOMMENDATIONS | 第138-141页 |
| CONCLUSIONS | 第138-140页 |
| RECOMMENDATIONS | 第140-141页 |
| KEY INNOVATIONS | 第141-142页 |
| PUBLISHED ARTICLES | 第142-143页 |
| APPENDICES | 第143-145页 |
