| ACKNOWLEDGEMENTS | 第5-6页 |
| ABSTRACT | 第6-7页 |
| LIST OF FIGURES | 第12-14页 |
| LIST OF TABLES | 第14-15页 |
| CHAPTER 1 INTRODUCTION | 第15-25页 |
| 1.1 SURGICAL SITE INFECTIONS | 第15-17页 |
| 1.1.1 The most common bacterial pathogens | 第15-16页 |
| 1.1.2 Risks and precaution | 第16-17页 |
| 1.2 SURGICAL SUTURES | 第17-19页 |
| 1.2.1 Classification of sutures | 第17-18页 |
| 1.2.2 Suture performance requirements | 第18-19页 |
| 1.3 SILK AS A MEDICAL SUTURE MATERIAL | 第19-20页 |
| 1.3.1 Silk sutures | 第19页 |
| 1.3.2 Advantages of silk sutures | 第19页 |
| 1.3.3 Disadvantages of silk sutures | 第19-20页 |
| 1.4 ANTIMICROBIAL SUTURES | 第20-23页 |
| 1.4.1 The role of antimicrobial sutures | 第20页 |
| 1.4.2 Antimicrobial agents & antimicrobial coatings | 第20-21页 |
| 1.4.3 Previous research on antimicrobial sutures | 第21-23页 |
| 1.5 RESEARCH CONTENTS (GOAL OF STUDY) | 第23-25页 |
| 1.5.1 Objectives of research project | 第23页 |
| 1.5.2 Theoretical or conceptual frame work | 第23-24页 |
| 1.5.3 Key of problem | 第24-25页 |
| CHAPTER 2 EXPERIMENTAL MATERIALS AND METHODS | 第25-34页 |
| 2.1 EXPERIMENTAL DESIGN | 第25-26页 |
| 2.2 MATERIALS AND EQUIPMENT | 第26-29页 |
| 2.2.1 Suture material | 第26页 |
| 2.2.2 Antibacterial agent | 第26页 |
| 2.2.3 Drug polymer career PCL | 第26-27页 |
| 2.2.4 Suture coating agent(PCL & SMZ) | 第27页 |
| 2.2.5 Test bacte rium | 第27-28页 |
| 2.2.6 Chemicals used | 第28页 |
| 2.2.7 Equipment used | 第28-29页 |
| 2.3 ASSESSING THE DRUG RESISTANCE OF THE TEST STRAINS AND EFFICIENCY OFANTIBACTERIAL AGENT | 第29-31页 |
| 2.3.1 Minimum inhibitory concentration(MIC) | 第29-30页 |
| 2.3.2 Minimum Inhibitory Concentration results | 第30-31页 |
| 2.4 SUTURE PRE TREATMENT WITH NaOH(SCOURING) | 第31页 |
| 2.5 SUTURE ANTIMICROBIAL TREATMENT | 第31-33页 |
| 2.5.1 Coating process | 第31-32页 |
| 2.5.2 Coating process optimization | 第32-33页 |
| 2.6 SUMMARY | 第33-34页 |
| CHAPTER 3 ANTIBACTERIAL PROPERTY PERFORMANCE EVALUATION | 第34-47页 |
| 3.1 ZONE OF INHIBITION ASSAY | 第34-40页 |
| 3.1.1 Zone of inhibition for SMZ only and SMZ+PCL treated sutures | 第35-36页 |
| 3.1.2 Zone of inhibition at different Molecular weights of PCL | 第36-37页 |
| 3.1.3 Zone of inhibition at different dip coating times | 第37-38页 |
| 3.1.4 Zone of inhibition at different PCL concentrations | 第38-39页 |
| 3.1.5 Zone of inhibition for pre treated sutures with NaOH | 第39-40页 |
| 3.2 ANTIBACTERIAL LASTING AND PERSISTENCE TESTS | 第40-44页 |
| 3.2.1 Sustained efficacy Assay | 第40-41页 |
| 3.2.2 Sustained efficacy results for sutures coated with low molecular weight PCL (80 000Mw)PCL | 第41-42页 |
| 3.2.3 Sustained efficacy results for sutures coated with high molecular weight PCL(180 000Mw) | 第42-43页 |
| 3.2.4 Sustained efficacy results for sutures coated pre-treated with NaOH | 第43-44页 |
| 3.3 ANTIMICROBIAL SUTURE RELEASE KINETICS | 第44-46页 |
| 3.3.1 The measurement of drug release | 第44-45页 |
| 3.3.2 The drug release results for coated silk sutures | 第45-46页 |
| 3.4 SUMMARY | 第46-47页 |
| CHAPTER 4 PHYSICAL＆MECHANICAL PERFORMANCE EVALUATION | 第47-55页 |
| 4.1 SURFACE MORPHOLOGICAL ANALYSIS | 第47-49页 |
| 4.1.1 Preparation of suture for SEM testing | 第47-48页 |
| 4.1.2 SEM test results | 第48-49页 |
| 4.2 DIAMETER CHANGES AS COATING PROCESS IS OPTIMIZED | 第49-52页 |
| 4.2.1 Effect of changing coating process parameters on suture diameter | 第50-51页 |
| 4.2.2 Percentage coating agent add-on,on suture diameter at different immersion times | 第51-52页 |
| 4.3 STRENGTH TESTING | 第52-54页 |
| 4.4 SUMMARY | 第54-55页 |
| CHAPTER 5 COMPREHENSIVE EVALUATION OF ANTIBACTERIAL SUTURE | 第55-61页 |
| S.1 INFLUENCE OF THE PRESENCE OF PCL IN COATING AGENT | 第55-58页 |
| 5.1.1 The basis Of using PCL | 第55-56页 |
| 5.1.2 Antimicrobial influence | 第56-57页 |
| 5.1.3 Mechanical property influence | 第57页 |
| 5.1.4 Influence on drug release | 第57-58页 |
| 5.2 THE INFLUENCE OF DIFFERENT PCL PARAMETERS | 第58-59页 |
| 5.2.1 Molecular weight | 第58-59页 |
| 5.2.2 Different PCL concentrations | 第59页 |
| 5.3 INFLUENCE OF TIME OF IMMERSION OF SUTURE IN COATING AGENT | 第59-60页 |
| 5.4 INFLUENCE OF SUTURE PRE TREATMENT WITH NAOH | 第60页 |
| 5.5 SUMMARY | 第60-61页 |
| CHAPTER 6 CONCLUSION AND FUTURE OUTLOOK | 第61-63页 |
| 6.1 CONCLUSION | 第61-62页 |
| 6.2 FUTURE OUTLOOK | 第62-63页 |
| REFERENCES | 第63-69页 |
| PUBLICATIONS DURING GRADUATE STUDY | 第69-70页 |
| APPENDIX | 第70-73页 |
