| 摘要 | 第4-11页 |
| Abstract | 第11-13页 |
| Chapter 1 Introduction | 第17-37页 |
| 1.1 Gastritis, Atrophic Gastritis and Gastric intestinal metaplasia | 第18-19页 |
| 1.2 GIM in endoscopically diagnosed AG patients | 第19-28页 |
| 1.2.1 Methods | 第20-21页 |
| 1.2.2 Results | 第21-25页 |
| 1.2.3 Comparison of results with Other Studies | 第25-28页 |
| 1.3 Helicobacter Pylori | 第28-32页 |
| 1.4 CDX2 and intestinal differentiation | 第32-36页 |
| 1.4.1 CDX2 and Gastric carcinogenesis | 第33-36页 |
| 1.4.2 CDX2 and H.pylori | 第36页 |
| 1.5 Objectives | 第36-37页 |
| Chapter 2 Literature Review: GIM as a gastric premalignant lesion | 第37-50页 |
| 2.1 Introduction | 第37页 |
| 2.2 Presentation, Diagnosis and Classification of GIM | 第37-39页 |
| 2.3 Gastric Intestinal Metaplasia at molecular level | 第39-43页 |
| 2.4 Etiology and Prevalence of GIM | 第43-44页 |
| 2.5 Treatment options for Gastric Intestinal Metaplasia | 第44-47页 |
| 2.6 Is there a need for Surveillance? | 第47-50页 |
| Chapter 3 Materials and Methods | 第50-51页 |
| 3.1 H.pylori detection and IHC analysis for CDX2 | 第50页 |
| 3.2 Statistical Analysis | 第50-51页 |
| Chapter 4 Results | 第51-57页 |
| 4.1 CDX2 expression in Gastric Intestinal Metaplasia | 第51页 |
| 4.2 Correlation between H.pylori and CDX2 expression | 第51-57页 |
| Chapter 5 Discussion and Conclusion | 第57-63页 |
| 5.1 Is CDX2 expression consistent during all stages of gastriccarcinogenesis? | 第57-59页 |
| 5.2 Does H.pylori induce CDX2 expression? | 第59-61页 |
| 5.3 Conclusion | 第61-63页 |
| References | 第63-79页 |
| Introduction to Author | 第79-80页 |
| ACKNOWLEDGEMENTS | 第80-81页 |
