| Acknowledgements | 第8-10页 |
| Abstract | 第10-11页 |
| Glossary of abbreviations | 第12-16页 |
| Chapter 1: 2,3-Naphthalimide and recent progress | 第16-38页 |
| 1.1 Introduction | 第16-19页 |
| 1.2 As an environment-sensitive fluorophore | 第19-24页 |
| 1.3 Large ratiometric DNA detection and white organic light-emitting devices(New lighting sources) | 第24-25页 |
| 1.4 Large stokes shift and solvatochromic fluorophore | 第25-28页 |
| 1.5 Antitumor agents | 第28-38页 |
| Chapter 2: Design,synthesis and characterization of novel 6-sub-2,3-naphthalicanhydrides andnaphthalimide analogous | 第38-83页 |
| 2.1 Design,synthesis and characterizing novel 6-sub-2,3-naphthalicanhydrides and naphthalimideanalogous | 第39页 |
| 2.2 Abstract | 第39-40页 |
| 2.3 Introduction | 第40-43页 |
| 2.4 Short and scalable synthesis of anhydride precursor of environment-sensitive fluorophore 6-DMN | 第43-46页 |
| 2.5 Short and efficient regio selective synthesis of other 6-substituted 2,3-naphthalimides | 第46-52页 |
| 2.6 The design strategy and synthesis of 2-hydroxy-1H-benzo[f]isoindole-1,3(2H)-dione | 第52-61页 |
| 2.7 Experimental data | 第61-83页 |
| 2.7.1 General preparation of N-(aminoalkyl) imides | 第71-74页 |
| 2.7.2 General preparation of N-(H) imides | 第74-76页 |
| 2.7.3 General procedure for the synthesis of N-(aminophenyl)imides (d,h,l,p,t) | 第76-77页 |
| 2.7.4 General procedure of 6-sub-N-hydroxy-2,3-naphthalene-dicarboximide | 第77-78页 |
| 2.7.5 General procedure of 6-sub-1,3-dioxo-1H-benzo-[f]isoindol-2-(3H)-ylalkyl/arylsulfonate | 第78-80页 |
| 2.7.6 General procedure of 6-sub-1,3-dioxo-1H-benzo-[f]isoindol-2-(3H)-yl 4-methylbenzenesulfonate | 第80-83页 |
| Chapter 3: Photophysical properties of 6-sub-1-alkyl and 6-sub-1-aryl-2,3-naphthalimides | 第83-106页 |
| 3.1 Introduction | 第83-86页 |
| 3.2 Preferred probe properties | 第86-87页 |
| 3.3 Fluorescence quantum yields | 第87-88页 |
| 3.4 The 6-sub-2,3-naphthalimide fluorophore | 第88-89页 |
| 3.5 Unusual large Stokes shifts and solvatochromic fluorophore:Synthesis, spectra, solvent effect of6-substituted 2,3-naphthalimide | 第89-106页 |
| 3.5.1 Absorption and emission spectra | 第89-106页 |
| Chapter 4: Biological Evaluation of 2-hydroxy-1H-benzo-[f]isoindole-1,3(2H)-dione | 第106-128页 |
| 4.1 Abstract | 第106-107页 |
| 4.2 Introduction | 第107-108页 |
| 4.3 Cytotoxic evaluation in vitro | 第108-110页 |
| 4.3.1 Result and Discussions | 第110页 |
| 4.4 6-Sub-2,3-naphthalimide as a DNA intercalate | 第110-115页 |
| 4.4.1 Introduction | 第110-112页 |
| 4.4.2 Result and Discussion | 第112-115页 |
| 4.5 Fluorescent markers for hypoxic cells of 6-sub-2,3-naphthalimide | 第115-128页 |
| 4.5.1 Introduction | 第116-117页 |
| 4.5.2 Result and Discussion | 第117-120页 |
| 4.5.3 Quantitative analysis of cell fluorescence | 第120页 |
| 4.5.4 Two fluorescent probes on cell markers | 第120-128页 |
| CONCLUSION | 第128-130页 |
| PUBLICATIONS | 第130-131页 |
| REFERENCES | 第131-140页 |
