| Chapter 1． Literature Review | 第1-22页 |
| 1．1 Introduction | 第8页 |
| 1．2 The neonicotinoids | 第8-15页 |
| 1．2．1 Imidacloprid | 第9-11页 |
| 1．2．2 Thiacloprid | 第11-15页 |
| 1．2．2．1 Introduction | 第11-12页 |
| 1．2．2．2 Synthesis | 第12-15页 |
| 1．3 Neonicotinoid Insecticide Receptors | 第15-19页 |
| 1．3．1 Introduction | 第15-16页 |
| 1．3．2 Structure and diversity of insect nAChRs | 第16-18页 |
| 1．3．3 The existence of insect nAChR subtypes | 第18-19页 |
| 1．4 Proposal | 第19-22页 |
| Chapter 2． Synthesis and biological activity of 2-(3-pyridyImethylamino)-4-substitutedphenyl-5, 5-dimethyl-1, 3, 2-dioxaphosphinane 2-sulfides | 第22-41页 |
| 2．1 Experimental Work | 第22-23页 |
| 2．1．1 Synthesis of 1 -(hetero)-aryl-2,2-dimethyl-1,3-propanediols | 第22页 |
| 2．1．2 Synthesis of 2-chloro-4-substituted phenyl-5, 5 -dimethyl-1,3, 2-dioxaphosphinane 2-sulfide | 第22页 |
| 2．1．3 General procedure for the synthesis of 2-(3-pyridylmethylamino)-4-substitutedphenyl-5,5-dimethyl-l,3, 2-dioxaphosphinane 2-sulfides | 第22-23页 |
| 2．1．4 Characterization | 第23页 |
| 2．2． Result and discussion | 第23-41页 |
| 2．2．1 Synthesis of l-(hetero)-aryl-2,2-dimethyl-l,3-propanediols | 第23-24页 |
| 2．2．2 Synthesis of 2-chloro-4-substituted phenyl-5, 5-dimethyl-l,3,2-dioxaphosphinane 2-sulfide | 第24-25页 |
| 2．2．3 Synthesis of 2-(3-pyridylmethylamino)-4-substitutedphenyl-5, 5-dimeth yl-1, 3, 2-dioxaphosphinane 2-sulfides | 第25-41页 |
| Chapter 3． SYNTHESIS AND BIOLOGICAL ACTIVITIES OF N-(3-PYRIDYLMETHYL)TRANS-CYCLOTHIOPHOSPHORYLTHIOUREAS | 第41-52页 |
| 3．1 Experimental | 第41-42页 |
| 3．1．1 General procedure for the synthesis of 6-Chloropyridin-3yl) methyl amine 34． | 第41页 |
| 3．1．2 General procedure for the synthesis of 2-isothiocyano-4-substitutedphenyl-5,5-dimethyl-2-sulfo-l, 3, 2-dioxaphosphinane 3 | 第41-42页 |
| 3．1．3 General procedure for the synthesis of the target compound II4 | 第42页 |
| 3．2 Result and discussion | 第42-52页 |
| 3．2．1 Synthesis of the target compound 114 | 第42-52页 |
| Chapter 4． Conclusion | 第52-54页 |
| Acknowledgement | 第54-55页 |
| References | 第55-60页 |
| Publications | 第60-61页 |
| Appendix | 第61-65页 |
