| Abstract | 第5-7页 |
| 摘要 | 第8-10页 |
| Abbreviations | 第10-12页 |
| List of Figures | 第12-13页 |
| List of Tables | 第13-14页 |
| Chapter 1 Review:Skin biology, Gsdma3 and Primary CicatricialAlopecias | 第14-48页 |
| 1.1 Skin biology | 第15-19页 |
| 1.2 Gasdermin(GSDM) family and Gsdma3 | 第19-23页 |
| 1.3 Primary Cicatricial Alopecias (PCAs) | 第23-37页 |
| References | 第37-48页 |
| Chapter 2:Identification of a novel Gsdma3 mutant mouse strainthrough ENU mutagenesis | 第48-60页 |
| Introduction | 第49-50页 |
| Materials and methods | 第50-54页 |
| Results | 第54-58页 |
| 2.1 Identification of ENU induced AE mutant mice | 第54-56页 |
| 2.2 AE is an allele with a point mutation of Gsdma3 | 第56-58页 |
| Discussion | 第58页 |
| References | 第58-60页 |
| Chapter 3:Misdifferentiation, hyperproliferation and bulge stem celldepletion in AE mice | 第60-79页 |
| Introduction | 第61-62页 |
| Materials and methods | 第62-67页 |
| Results | 第67-74页 |
| 3.1 Abnormal differentiation of epidermis, hair follicles and sebaceous glands in AEskin | 第67-69页 |
| 3.2 Increased BrdU~+ cells in the upper region of AE hair follicles | 第69-70页 |
| 3.3 Apoptosis is unchanged in AE skin | 第70-71页 |
| 3.4 Gradual depletion of bulge stem cells in AE skin | 第71-74页 |
| Discussion | 第74-76页 |
| References | 第76-79页 |
| Chapter 4:Skin inflammation leads to bulge stem cell destruction andalopecia in AE mice | 第79-98页 |
| Introduction | 第80-81页 |
| Materials and methods | 第81-83页 |
| Results | 第83-91页 |
| 4.1 AE mice have an inflammatory condition in skin | 第83-87页 |
| 4.2 Collapse of immune privilege in bulge stem cells of AE mice | 第87-88页 |
| 4.3 Treatment of CsA recovers IP collapse in bulge, and is accompanied by inhibitionof inflammatory condition in AE mice | 第88-90页 |
| 4.4 Treatment of CsA reverses stem cells depletion and improves alopecia in AE | 第90-91页 |
| Discussion | 第91-95页 |
| References | 第95-98页 |
| Acknowledgements | 第98-99页 |
| Publication | 第99-101页 |
