| Abbreviations | 第1-10页 |
| 摘要 | 第10-13页 |
| Abstract | 第13-16页 |
| General background | 第16-39页 |
| Definition and epidemiology of congenital heart disease | 第16页 |
| Classification of congenital heart disease | 第16-18页 |
| Treatment of congenital heart disease | 第18-19页 |
| Mechanism of congenital heart disease | 第19-32页 |
| Single nucleotide polymorphism and congenital heart disease | 第32-39页 |
| Part I MicroRNA Gene Polymorphisms and Congenital Heart Disease | 第39-74页 |
| Background | 第40-46页 |
| MicroRNA | 第40-44页 |
| The microRNA and congenital heart disease | 第44-45页 |
| Current challenges and hypothese | 第45-46页 |
| Methods | 第46-59页 |
| Results | 第59-67页 |
| Discussion | 第67-74页 |
| Lesson 1: MicroRNA-196a2 SNP rs11614913 increase 1.48-fold CHD risk | 第67-68页 |
| Lesson 2: MicroRNA-196a2 SNP rs11614913 enhances processing from pre-hsa-mir-196a2 to its mature form | 第68-69页 |
| Lesson 3: MicroRNA-196a2 SNP rs11614913 strengthens targeting binding of hsa-mir-196a2-3p | 第69-70页 |
| Lesson 4: miR-196a2 rs11614913 may contribute to CHD etiology by influencing miR-196a-HOXB8-Shh signaling | 第70-74页 |
| Part II Folate Metabolism Enzymes Gene polymorphisms and Congenital Heart Disease | 第74-94页 |
| Background | 第75-80页 |
| Folate, homocysteine and congenital heart disease | 第75-77页 |
| Single nucleotide polymorphisms of folate metabolism enzymes gene and congenital heart disease | 第77-79页 |
| Current challenges and hypothese | 第79-80页 |
| Methods | 第80-83页 |
| Results | 第83-91页 |
| Discussion | 第91-94页 |
| Lesson 5: Folate metabolism pathway gene MTHFR polymorphism 1793G>A was associated with a significantly decreased risk of congenital heart disease | 第91-92页 |
| Lesson 6: The main protective effect of MTHFR gene polymorphism 1793G>A is on isolated perimembranous ventricle septal defect patients | 第92-94页 |
| Main conclusions | 第94-95页 |
| Review | 第95-116页 |
| References | 第116-141页 |
| List of papers | 第141-166页 |
| Acknowledgements | 第166-168页 |
