| 摘要 | 第8-10页 |
| ABSTRACT | 第10-11页 |
| CHAPTER 1:INTRODUCTION | 第12-42页 |
| 1.1 Polymer Architecture | 第12-13页 |
| 1.2 Polymers as biomaterials | 第13页 |
| 1.3 Cationic ring opening polymerization (CROP) | 第13-15页 |
| 1.3.1 Cationic Ring-opening Polymerization (CROP) of Oxazolines | 第13-14页 |
| 1.3.2 Mechanism of Oxazoline Polymerization | 第14-15页 |
| 1.4 Functionalization of Polyoxazolines | 第15-19页 |
| 1.4.1 Functionalization via Initiator | 第16页 |
| 1.4.2 Functionalization via Termination | 第16-18页 |
| 1.4.3 Functionalization via monomer modification | 第18-19页 |
| 1.5 Topological Polymers of 2-alkyl-2-oxazoline | 第19-30页 |
| 1.5.1 Hyperbranched Polymers | 第19-27页 |
| 1.5.1.1 Single monomer method | 第19-23页 |
| 1.5.1.2 Double monomer method | 第23-25页 |
| 1.5.1.3 Well-Defined Dendrimers and Hyperbranched polymers | 第25-27页 |
| 1.5.2 Cyclic Polymers | 第27-30页 |
| 1.5.2.1 The Ring Closure Route | 第28-30页 |
| 1.5.3 Thiol/Disulfide exchange chemistry | 第30页 |
| 1.6 Polyethyleneimine | 第30-34页 |
| References | 第34-42页 |
| CHAPTER 2:CHARACTERIZATION TECHNIQUES | 第42-50页 |
| 2.1 Free Thiol Groups Quantification By Spectrophotometry UsingEllman's Assay | 第42页 |
| 2.2 Size exclusion Chromatography | 第42-48页 |
| 2.2.1 Brief History | 第43-44页 |
| 2.2.2 Basic principle of SEC | 第44-46页 |
| 2.2.4 SEC detectors | 第46页 |
| 2.2.5 Differential Refractometer detector for SEC | 第46-47页 |
| 2.2.6 Multi angle laser light scattering detector | 第47-48页 |
| 2.3 Mass spectrometry | 第48-49页 |
| 2.3.1 Matrix-Assisted Laser Desorption Ionization Time Of Flight Mass Spectrometry(MALDI-TOF-MS) | 第48-49页 |
| References | 第49-50页 |
| CHAPTER 3:HYPERBRANCHED POLY(2-ETHYL-2-OXAZOLINE)SYNTHESIS USING REVERSIBLE THIOL/DISULFIDE EXCHANGECHEMISTRY | 第50-74页 |
| 3.2 Introduction | 第51-53页 |
| 3.3 Experimental Section | 第53-56页 |
| 3.3.1 Materials | 第53页 |
| 3.3.2 Synthesis of three arm Star-PEtOx-Br macromonomer | 第53-54页 |
| 3.3.3 End capping of the three arms Star-PEtOx-Br macromonomer | 第54页 |
| 3.3.4 Synthesis of the Linear-PEtOx-Br polymer | 第54页 |
| 3.3.5 End capping of the Linear-PEtOx-Br polymer | 第54-55页 |
| 3.3.6 Synthesis of the hyperbranched PEtOx | 第55页 |
| 3.3.7 Reduction of the hyperbranched PEtOx | 第55页 |
| 3.3.8 Hydrolysis of PEtOx to polyethyleneimine | 第55页 |
| 3.3.9 Free thiol groups determination by spectrophotometry using Ellman's reagent | 第55-56页 |
| 3.3.10 Cell viability assay | 第56页 |
| 3.4 Characterization | 第56页 |
| 3.5 Results and Discussion | 第56-69页 |
| 3.6 Conclusion | 第69-71页 |
| References | 第71-74页 |
| CHAPTER 4:SYNTHESIS OF CYCLIC POLY(2-ETHYL-2-OXAZOLINE) WITHBIODEGRADABLE DISULFIDE BONDS | 第74-90页 |
| 4.2 Introduction | 第75-77页 |
| 4.3 Experimental Section | 第77-80页 |
| 4.3.1 Materials | 第77页 |
| 4.3.2 Synthesis of Linear Br-PEtOx-Br macromonomer | 第77-78页 |
| 4.3.3 Synthesis of PEtOx-2Xanthate macromonomer | 第78页 |
| 4.3.4 Synthesis of the cyclic PEtOx with disulfide bond | 第78页 |
| 4.3.5 Reduction of the Cyclic-PEtOx | 第78-79页 |
| 4.3.6 Ellman's assay for thiol group determination | 第79页 |
| 4.3.7 Synthesis of the Alkyne-PEtOx-N_3 | 第79页 |
| 4.3.8 Synthesis of cyclic PEtOx using alkyne-azide click chemistry | 第79-80页 |
| 4.4 Characterization | 第80页 |
| 4.5 Results and discussion | 第80-87页 |
| 4.6 Conclusions | 第87-88页 |
| References | 第88-90页 |
| CHAPTER 5:A NOVEL INITIATOR CONTAINING ALKYNE GROUP FOR THEPOLYMERIZATION OF 2-ETHYL-2-OXAZOLINE | 第90-110页 |
| 5.2 Introduction | 第91-93页 |
| 5.3 Experimental Section | 第93-97页 |
| 5.3.1 Materials | 第93页 |
| 5.3.2 Synthesis of the compound Alkyne-HPD | 第93-94页 |
| 5.3.3 Synthesis of the compound Alkyne-2OH | 第94页 |
| 5.3.4 Synthesis of the trifunctional initiator 1 (Alkyne-2OTf) | 第94页 |
| 5.3.5 Synthesis of the two arm alkyne functionalized macromonomer(Alkyne-PEtOx-2OTf) | 第94页 |
| 5.3.6 Azidation of Alkyne-PEtOx-2OTf (Alkyne-PEtOx-2N_3) | 第94-95页 |
| 5.3.7 Synthesis of the Polymer Alkyne-PEtOx-triazole-1,1'-bis(4-phenyl) | 第95页 |
| 5.3.8 Synthesis of the trifunctional initiator 2 (Alkyne-2OTs) | 第95-96页 |
| 5.3.9 Synthesis of Alkyne functionalized macromonomer with two arms(Alkyne-PEtOx-2OTs) | 第96页 |
| 5.3.10 Synthesis of the compound Alkyne-OH | 第96页 |
| 5.3.11 Synthesis of the difunctional initiator 3 (Alkyne-1OTs) | 第96页 |
| 5.3.12 Synthesis of the alkyne functionalized macromonomer(Alkyne-PEtOx-OTs) | 第96-97页 |
| 5.4 Characterization | 第97页 |
| 5.5 Results and Discussion | 第97-105页 |
| 5.6 Conclusion | 第105-107页 |
| References | 第107-110页 |
| CONCLUSION | 第110-112页 |
| ACKNOWLEDGMENT | 第112-114页 |
| LIST OF PUBLICATIONS | 第114页 |
