| Abstract | 第1-7页 |
| 中文摘要 | 第7-9页 |
| Abbreviations | 第9-13页 |
| Chapter Ⅰ Review:PP2A and erythropoiesis | 第13-45页 |
| ·PP2A is a serine/threonine phosphatase | 第14-23页 |
| Kinases, phosphatases and PSPs | 第14-16页 |
| PP2A holoenzyme holds a comprehensive structure | 第16-18页 |
| Cellular localization and multi-step regulation | 第18-20页 |
| Chemical inhibitors, human diseases and animal models | 第20-23页 |
| ·Hematopoiesis and erythropoiesis-keeping life going on | 第23-33页 |
| Insights into hematopoiesis-hot spring for blood cells | 第23-27页 |
| The biology of erythropoiesis-keeping blood red | 第27-33页 |
| References | 第33-45页 |
| Chapter Ⅱ Loss of Ppp2ca allele in Tie2~+ tissues leads to fetal liver anemia | 第45-74页 |
| Introduction | 第46-49页 |
| Materials and methods | 第49-54页 |
| ·Establish Ppp2ca conditional knockout mice | 第54-55页 |
| ·Loss of the Ppp2ca allele within Tie2~+ cells results in embryonic lethality | 第55-56页 |
| ·Mutant embryos exhibit normal vasculature | 第56-57页 |
| ·PP2Acα-deficient embryos suffer impaired defective hematopoiesis | 第57-65页 |
| ·Adult mutant mice manifest normal hematopoietic parameters | 第65-67页 |
| Discussion | 第67-70页 |
| Contributions | 第70页 |
| References | 第70-74页 |
| Chapter Ⅲ Elevated erythroid apoptosis and impaired STAT5-Bcl-x_L axis inPP2Acα-deficient embryos | 第74-90页 |
| Introduction | 第75-76页 |
| Materials and methods | 第76-79页 |
| ·Initial seeding of fetal liver with hematopoietic progenitors in mutant embryos isnot down-regulated | 第79-80页 |
| ·Decreased in vivo proliferation in mutant fetal livers | 第80-81页 |
| ·Increased apoptosis in cultured PP2Aca-deficient committed erythroid cells | 第81-82页 |
| ·Impaired STAT5-Bcl-x_L signaling is responsive for reduced cell survival of mutanterythroids | 第82-84页 |
| Discussion | 第84-86页 |
| Contributions | 第86页 |
| References | 第86-90页 |
| Acknowledgments | 第90-92页 |
| Publications | 第92-94页 |
