| Abstract (Chinese) | 第1-12页 |
| Abstract (English) | 第12-20页 |
| Section I: Neonatal genistein exposure increases estrogen receptor (ER) alpha and insulin-like growth factor-I (IGF-I) receptor expression in the development of uterine leiomyoma | 第20-35页 |
| Introduction | 第20-21页 |
| Materials and methods | 第21-24页 |
| Results | 第24-27页 |
| Discussion | 第27-31页 |
| References | 第31-35页 |
| Section II: In vitro study: the effects of genistein on human uterine leiomyoma cells and normal uterine smooth muscle cells | 第35-53页 |
| Introduction | 第35-36页 |
| Materials and methods | 第36-41页 |
| Results | 第41-47页 |
| Discussion | 第47-50页 |
| References | 第50-53页 |
| Section III: Insights from toxicogenomics: High-dose of genistein down-regulates TGF-beta pathway genes in human uterine leiomyoma cells | 第53-79页 |
| Introduction | 第53-54页 |
| Materials and methods | 第54-59页 |
| Results | 第59-74页 |
| Discussion | 第74-77页 |
| References | 第77-79页 |
| Section IV: Low-dose genistein promotes the interactions between estrogen receptor alpha and insulin-like growth factor-I receptor leading to uterine leiomyoma cell proliferation | 第79-105页 |
| Introduction | 第79-80页 |
| Materials and methods | 第80-85页 |
| Results | 第85-94页 |
| Discussion | 第94-100页 |
| References | 第100-105页 |
| Supplements | 第105-138页 |
| Supplement I Abbreviations | 第105-106页 |
| Supplement II Design of the project and funding | 第106-109页 |
| Supplement III Papers published (or submitted) during pre-doctoral period | 第109-110页 |
| Supplement IV Another project finished during the pre-doctoral period | 第110-138页 |
| Acknowledgements | 第138-139页 |
| 致谢 | 第139-140页 |
