| Abstract | 第1-9页 |
| 中文摘要 | 第9-11页 |
| Abbreviations | 第11-12页 |
| Chapter1:Literature review of idiopathic pulmonary fibrosis | 第12-33页 |
| ·Clinical description of IPF | 第12-14页 |
| ·Pathogenesis of IPF | 第14-21页 |
| ·IPF results from epithelial injury and abnormal wound healing | 第14-16页 |
| ·Myofibroblasts in IPF | 第16页 |
| ·Origin of myofibroblasts in IPF | 第16-19页 |
| ·TGF-β1:a novel target for treatment of IPF | 第19-21页 |
| ·Animal models of pulmonary fibrosis | 第21-24页 |
| References | 第24-33页 |
| Chapter 2:Hyploinsufficiency of Fstl1 suppresses bleomycin-inducedpulmonary fibrosis | 第33-96页 |
| 1. Introduction | 第33-34页 |
| 2. Materials and methods | 第34-45页 |
| 3. Results | 第45-85页 |
| Section Ⅰ. Altered expression of FSTL1 in IPF patients | 第45-51页 |
| ·Microarray analysis of FSTL1 in IPF patients and controls | 第45-47页 |
| ·FSTL1 expression in lung tissues of IPF patients and controls | 第47-48页 |
| ·FSTL1 expression in PPFs from IPF patients and controls | 第48-49页 |
| ·Fstl1 expression in lung tissues of mice after bleomycin treatment | 第49-50页 |
| ·Fstl1 expression PPFs from mice after bleomycin treatment | 第50页 |
| ·Localization of Fstl1 in lungs from mice after bleomycin treatment | 第50-51页 |
| ·Conclusions | 第51页 |
| Section Ⅱ.Fstl1~(+/-) mice have an attenuated fibrotic phenotype afterbleomycin-induced lung injury | 第51-60页 |
| ·Expression of Fstll in Fstl1~(+/-) mice and WT controls after bleomycintreatment | 第51-53页 |
| ·Survival curve of Fstl1~(+/-) mice and WT controls after bleomycin treatment | 第53-54页 |
| ·Histological analysis of lung tissues from Fstl1~(+/-) mice and WT controls afterbleomycin treatment | 第54-56页 |
| ·Collagen deposition of lung tissues from Fstl1~(+/-) mice and WT controls afterbleomycin treatment | 第56-57页 |
| ·ECM deposition of lung tissues from Fstl1~(+/-) mice and WT controls afterbleomycin treatment | 第57-59页 |
| ·Conclusions | 第59-60页 |
| Section Ⅲ.Fstl1~(+/-) mice showed a normal acute response to bleomycin-inducedlung injury | 第60-64页 |
| ·Total and differential inflammatory cells in BAL fluid | 第60-61页 |
| ·Leukocyte and macrophage Subsets in whole lung tissues | 第61-63页 |
| ·Th1/2 cytokines in BAL fluid and lung tissues | 第63页 |
| ·Conclusions | 第63-64页 |
| Section Ⅳ Fstl1~(+/-) mice exhibited reduced EMT process in response to bleomycin | 第64-69页 |
| ·Decreased accumulation of myofibroblasts in Fstl1~(+/-) lungs afterbleomycin-induced injury | 第64-66页 |
| ·Reduced EMT in Fstl1~(+/-) lungs during tissue injury | 第66-68页 |
| ·Conclusions | 第68-69页 |
| Section Ⅴ.Fstl1 exerts its pro-finbrotic role through modulating TGF-β signaling | 第69-85页 |
| ·TGF-β1 induced Fstl1 expression in mouse lung fibroblasts and epithelial cells | 第69-70页 |
| ·Fstl1 deletion suppresses TGF-β1-induced myofibroblasts activation and ECMproduction in lung fibroblasts | 第70-72页 |
| ·Fstl1 promotes TGF-β1-induced EMT in vitro | 第72-75页 |
| ·Fstl1 modulates TGF-β1-induced EMT via Smad signaling | 第75-79页 |
| ·Fstl1 modulates TGF-β1-induced EMT via MAPK signaling | 第79-81页 |
| ·Fstl1 binds to TGF-β1 in vitro | 第81-84页 |
| ·Conclusions | 第84-85页 |
| 4. Conclusions and Discussions | 第85-90页 |
| References | 第90-96页 |
| Acknowledgments | 第96-97页 |
| Publication | 第97-98页 |
