| Abbreviations | 第8-10页 |
| Chapter 1.Effect of propofol on spontaneous activity of cerebellar Purkinje cells in vivo inmice | 第10-40页 |
| Abstract | 第11-14页 |
| 摘要 | 第14-16页 |
| 1.1 Introduction | 第16-19页 |
| 1.2 Materials and methods | 第19-22页 |
| 1.2.1 Animals and Anesthesia | 第19页 |
| 1.2.2 Experiment Equipment | 第19页 |
| 1.2.3 Surgical procedures | 第19-20页 |
| 1.2.4 Electrophysiological recordings | 第20-21页 |
| 1.2.5 Drug administration | 第21页 |
| 1.2.6 Statistical analysis | 第21-22页 |
| 1.3 Results | 第22-30页 |
| 1.3.1 Cerebellar surface application of propofol depressed SS firing rate of PCs | 第22-25页 |
| 1.3.2 Blockade of GABA_A and GABA_B receptors activity did not prevented thepropofol-induced depression of PC SS firing rate | 第25-28页 |
| 1.3.3 Simultaneously blocking glycine and GABA_A receptors activity abolished thepropofol-induced depression of PC SS firing rate | 第28-30页 |
| 1.4 Discussion | 第30-34页 |
| 1.4.1 Propofol and GABAergic transmission | 第30-31页 |
| 1.4.2 Propofol depressed cerebellar PC SS firing rate via activation of both GABA_Aand glycine receptors activity | 第31-34页 |
| 1.5 Conclusion | 第34-35页 |
| References | 第35-40页 |
| Chapter 2.Effect of propofol on sensory information transmission of cerebellar Purkinjecells in vivo in mice | 第40-67页 |
| Abstract | 第41-44页 |
| 摘要 | 第44-46页 |
| 2.1 Introduction | 第46-49页 |
| 2.2 Materials and Methods | 第49-53页 |
| 2.2.1 Animals and Anesthesia | 第49页 |
| 2.2.2 Experiment Equipment | 第49页 |
| 2.2.3 Surgical procedures | 第49-51页 |
| 2.2.4 Electrophysiological recordings | 第51页 |
| 2.2.5 Drug administration | 第51页 |
| 2.2.6 Statistical analysis | 第51-53页 |
| 2.3 Results | 第53-58页 |
| 2.3.1 Effects of propofol on the sensory stimulation evoked responses of PCs | 第53-55页 |
| 2.3.2 Effects of propofol on facial stimulation evoked responses in cerebellar PCs inthe absence of GABA_A receptor activity | 第55-58页 |
| 2.4 Discussion | 第58-62页 |
| 2.4.1 Propofol inhibited sensorry stimulation evoked GABAergic responses of PCs | 第58-60页 |
| 2.4.2 Propofol enhanced the sensory stimulation evoked parallel fiber-PCs excitatorytransmission | 第60-62页 |
| 2.5 Conclusions | 第62-63页 |
| References | 第63-67页 |
| Review:Effects of propofol on central nervous system | 第67-87页 |
| References | 第79-87页 |
| Publication | 第87-88页 |
| 致谢 | 第88页 |
