| ABSTRACT | 第7-9页 |
| 1 INTRODUCTION | 第15-17页 |
| 2 LITERATURE REVIEW (BACKGROUND) | 第17-26页 |
| 2.1 Drug delivery | 第17页 |
| 2.2 Importance of drug delivery via scaffolds | 第17-19页 |
| 2.3 Importance of ultrafine fibrous 3D scaffolds in tissue engineering | 第19-20页 |
| 2.4 Limitations of ultrafine fibrous 2D scaffolds | 第20-21页 |
| 2.5 Fabrication of Ultrafine fibrous 3D scaffolds | 第21-23页 |
| 2.6 Use of proteins in tissue engineering and drug delivery | 第23-24页 |
| 2.7 Scopes of UF 3D protein scaffolds produced via ULCPS in TE and DD | 第24-26页 |
| 3 RESEARCH OBJECTIVES | 第26-27页 |
| 4 EXPERIMENTAL | 第27-38页 |
| 4.1 Materials | 第27页 |
| 4.2 Methods | 第27-38页 |
| 4.2.1 Preparation of polymer solutions | 第27页 |
| 4.2.2 Preparation of UF3DS from RSF, FB and Gt by ULCPS | 第27-28页 |
| 4.2.3 Morphology observation of uncrosslinked and crosslinked scaffolds with CA | 第28页 |
| 4.2.4 Water stability test of the scaffolds | 第28页 |
| 4.2.5 Fabrication of drug loaded ultrafine fibrous 3D scaffolds from gelatin | 第28-29页 |
| 4.2.6 Fabrication of 2D electrospun scaffolds from gelatin as control | 第29-31页 |
| 4.2.7 Morphology observation of drug loaded scaffolds | 第31页 |
| 4.2.8 Drug loading and release calibration | 第31-33页 |
| 4.2.9 Drug loading test | 第33页 |
| 4.2.10 Drug release experiments | 第33-34页 |
| 4.2.11 Degradation behavior of drug loaded scaffolds | 第34-35页 |
| 4.2.12 Fourier Transformation Infrared Spectroscopy of diclofenac sodium | 第35页 |
| 4.2.13 High performance liquid chromatography (HPLC) of released drug | 第35-36页 |
| 4.2.14 Statistical analysis | 第36-38页 |
| 5 RESULTS AND DISCUSSION | 第38-55页 |
| 5.1 Effect of polymer concentration on scaffold morphology | 第38-39页 |
| 5.2 Effect of crosslinker amount on the water stability of the scaffolds | 第39-42页 |
| 5.3 Morphology of drug loaded scaffolds | 第42-43页 |
| 5.4 Drug loading and release calibration curves | 第43-44页 |
| 5.5 Drug loading amounts | 第44-46页 |
| 5.6 Drug release profile | 第46-49页 |
| 5.7 Degradation behavior of the drug loaded scaffolds | 第49-52页 |
| 5.8 Functionality of diclofenac sodium before and after crosslinking | 第52-55页 |
| 6 CONCLUSIONS | 第55-56页 |
| 7 RECOMMENDATIONS FOR FUTURE WORKS | 第56-57页 |
| 8 REFERENCES | 第57-64页 |
| ACKNOWLEDGEMENTS | 第64-65页 |
| APPENDICES | 第65-94页 |
