| Abstract | 第1-7页 |
| 中文摘要 | 第7-9页 |
| Abbreviations | 第9-11页 |
| Review Urinary System Development and the potential BMP inhibitor, FSTL1 | 第11-45页 |
| Development of urinary tract | 第12-17页 |
| Hydroureter | 第17-23页 |
| BMP signal and urinary tract development | 第23-27页 |
| The biology of FSTL1 | 第27-37页 |
| Reference | 第37-45页 |
| Chapter 1 Fstl1 deficient mice develop congenital hydroureter and hydronephrosis | 第45-61页 |
| 1. Introduction | 第46-49页 |
| 2. Materials and Methods | 第49-52页 |
| 3. Result | 第52-58页 |
| ·Fstl1~(-/-) mice developed congenital hydroureter from E16.0 | 第52-55页 |
| ·Fstl1~(-/-) mice developed congenital hydronephrosis from E17.5 | 第55-56页 |
| ·No physical blockage along the urinary tract of Fstl1~(-/-) embryo | 第56-58页 |
| 4. Discussion | 第58-59页 |
| Reference | 第59-61页 |
| Chapter 2 The expression pattern of Fstl1~(-/-) in developing and adult urinary tract | 第61-71页 |
| 1. Introduction | 第62页 |
| 2. Mateirals and Methods | 第62-64页 |
| 3. Result | 第64-69页 |
| ·Fstl1 expression in development murine urinary tract | 第64-66页 |
| ·FSTL1 expression in adult mouse tissues | 第66-69页 |
| 4. Discussion | 第69-70页 |
| Reference | 第70-71页 |
| Chapter 3 Fstl1 regulates epithelial-mesenchymal interaction during ureter development | 第71-89页 |
| 1. Introduction | 第72-73页 |
| 2. Materials and Methods | 第73-77页 |
| 3. Result | 第77-85页 |
| ·Subepithelial ureteral mesenchymal cells were absent in Fstl1~(-/-) ureter | 第77-80页 |
| ·Defects in epithelial basement membrane in Fstl1~(-/-) ureter | 第80-82页 |
| ·Inactivation of Fstl1 resulted in defective proliferation and differentiation of ureteric epithelial cell | 第82-85页 |
| 4. Discussion | 第85-87页 |
| Reference | 第87-89页 |
| Chapter 4 Fsl1,regulates ureter development by modulating BMP signal | 第89-103页 |
| 1 Introduction | 第90-91页 |
| 2. Materials and Methods | 第91-94页 |
| 3. Result | 第94-99页 |
| ·Fstl1 deficiency caused up-regulation of pSMAD1/5/8 in developing ureter and kidney | 第94-96页 |
| ·Expression of ligands and receptors of BMP signal were not altered in Fstl1~(-/-) ureter | 第96页 |
| ·FSTL1 can antagonize BMP4-induced stimulation in vitro | 第96-99页 |
| 4. Discussion | 第99-101页 |
| Reference | 第101-103页 |
| Acknowledgment | 第103-104页 |
| Publication | 第104-106页 |
