| 中文摘要 | 第1-8页 |
| 英文摘要 | 第8-11页 |
| Chapter 1 Identification, Characterization and Functional Study of the Two Novel Human Members of Semaphorin Gene Family | 第11-47页 |
| 1． Introduction | 第12-13页 |
| 2． Materials and Methods | 第13-17页 |
| 3． Results | 第17-40页 |
| 3．1 Identification and Cloning of Human Semaphorin SEMA6C and SEMA6D | 第17-25页 |
| 3．2 The Genomic Structures and Chromosomal Localization of the Genes for Human SEMA6C and SEMA6D | 第25-26页 |
| 3．3 Distribution of SEMA6C and SEMA6D mRNAs | 第26-31页 |
| 3．4 Alternative Splicing of SEMA6C and SEMA6D | 第31-33页 |
| 3．5 Characterization of SEMA6C and SEMA6D | 第33-35页 |
| 3．6 Growth Cone Collapse Activity of SEMA6C and SEMA6D | 第35-40页 |
| 4． Discussion | 第40-43页 |
| References | 第43-47页 |
| Chapter 2: Characterization and Expression of Three Novel Differentiation-related Genes Belong to the Human NDRG Gene Family | 第47-64页 |
| 1． Introduction | 第48-49页 |
| 2． Materials and Methods | 第49-52页 |
| 3． Results | 第52-60页 |
| 3．1 Identification and cloning of human genes NDRG2, NDRG3 and NDRG4 | 第52页 |
| 3．2 Sequence analysis of human NDRG2, NDRG3 and NDRG4 proteins | 第52-55页 |
| 3．3 Chromosomal localization of the genes for human NDRG2, NDRG3 and NDRG4 | 第55-56页 |
| 3．4 Transcription profile of NDRG2, NDRG3 and NDRG4 | 第56-59页 |
| 3．5 Subcellular localization of NDRG2, NDRG3 and NDRG4 proteins | 第59-60页 |
| 4． Discussion | 第60-62页 |
| References | 第62-64页 |
| Chapter 3: Characterization and Tissue Expression of a Novel Human Gene npdc1 | 第64-79页 |
| 1． Introduction | 第64-65页 |
| 2． Materials and Methods | 第65-67页 |
| 3． Results and Discussion | 第67-77页 |
| 3．1 Identification and cloning of hnpdcl | 第67-68页 |
| 3．2 Sequence analysis of hNPDCl | 第68-70页 |
| 3．3 Chromosomal localization of the gene for hnpdcl | 第70-72页 |
| 3．4 Transcription profile of the hnpdcl gene in different human tissues | 第72-77页 |
| References | 第77-79页 |
| Chapter 4: Cloning, Chromosomal Assignment and Tissue Expression of a Novel Human Protein Tyrosine Phosphatase Gene | 第79-92页 |
| 1． Introduction | 第79-80页 |
| 2． Materials and Methods | 第80-82页 |
| 3． Results and Discussion | 第82-90页 |
| 3．1 Identification and cloning of human PTP-TD14 gene | 第82-85页 |
| 3．2 Sequence analysis of human PTP-TD14 | 第85-87页 |
| 3．3 Transcription profile of the human PTP-TD14 gene | 第87-88页 |
| 3．4 Chromosomal localization of the genes for human PTP-TD14 | 第88-90页 |
| References | 第90-92页 |
| Chapter 5: Cloning and Chromosomal Assignment of Six Novel Human Genes with Important Biological Functions | 第92-108页 |
| 1． Introduction | 第92-93页 |
| 2． Materials and Methods | 第93-94页 |
| 3． Results and Discussion | 第94-106页 |
| 3．1 Human BKLF gene | 第94-98页 |
| 3．2 Human c-Jun binding protein (JBP) gene | 第98页 |
| 3．3 Human hematopoietic zinc finger protein (Hzf) gene | 第98-101页 |
| 3．4 Human liver membrane-bound protein (LMP) gene | 第101页 |
| 3．5 Human liver nuclear protein LNP gene | 第101-104页 |
| 3．6 Human clathrin coat assembly protein (AP47) gene | 第104-106页 |
| References | 第106-108页 |
| 综述 Semaphorin及其受体的研究进展 | 第108-116页 |
| 附录一 英文缩写名 | 第116-117页 |
| 附录二 22 full-length cDNAs deposited in GenBank | 第117-118页 |
| 附录三 博士后期间申请(负责)的基金项目和专利项目 | 第118-119页 |
| 附录四 博士后期间完成的论文 | 第119-120页 |
| 致谢 | 第120页 |
